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Literature summary for 3.1.26.5 extracted from

  • Koski, R.A.; Bothwell, A.L.M.; Altman, S.
    Identification of a ribonuclease P-like activity from human KB cells (1976), Cell, 9, 101-116.
    View publication on PubMed
Search for more literature for 3.1.26.5

Inhibitors

Inhibitors Comment Organism Structure
tRNA
-
 Escherichia coli
tRNA
-
 Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
cytoplasm
-
 Homo sapiens 5737
-
additional information not detectable in nucleoplasm Homo sapiens
-
-

Metals/Ions

Metals/Ions Comment Organism Structure
K+
-
 Escherichia coli
K+ monovalent cation required: Na+, K+ or NH4+ Homo sapiens
Mg2+ required Escherichia coli
Mg2+ required Homo sapiens
Mg2+ optimal activity at 5 mM Homo sapiens
Na+ monovalent cation required: Na+, K+ or NH4+ Homo sapiens
NH4+
-
 Escherichia coli
NH4+ monovalent cation required: Na+, K+ or NH4+. Optimal NH4+ concentration is 200 mM Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
pre-tRNA + H2O Escherichia coli
-
 tRNA + 5'-oligoribonucleotide
-
 ?
pre-tRNA + H2O Homo sapiens involved in biosynthesis of KB cell tRNA tRNA + 5'-oligoribonucleotide
-
 ?

Organism

Organism UniProt Comment Textmining
Escherichia coli
-
-
-
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
KB cell tissue culture Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
pre-tRNA + H2O
-
 Escherichia coli tRNA + 5'-oligoribonucleotide
-
 ?
pre-tRNA + H2O involved in biosynthesis of KB cell tRNA Homo sapiens tRNA + 5'-oligoribonucleotide
-
 ?
pre-tRNA precursor + H2O single endonucleolytic scission in E. coli tRNATyr precursor, thereby separating the 41 extra nucleotides on the 5' end of the precursor molecule from the 5' terminal sequence of the mature tRNATyr molecule Escherichia coli tRNA + 5'-oligoribonucleotide
-
 ?
pre-tRNA precursor + H2O single endonucleolytic scission in E. coli tRNATyr precursor, thereby separating the 41 extra nucleotides on the 5' end of the precursor molecule from the 5' terminal sequence of the mature tRNATyr molecule Homo sapiens tRNA + 5'-oligoribonucleotide
-
 ?
pre-tRNA precursor + H2O E. coli tRNATyr precursor Escherichia coli tRNA + 5'-oligoribonucleotide
-
 ?
pre-tRNA precursor + H2O E. coli tRNATyr precursor Homo sapiens tRNA + 5'-oligoribonucleotide
-
 ?

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
8
-
-
 Escherichia coli
8
-
 broad optimum around pH 8.0 Homo sapiens

pH Range

pH Minimum pH Maximum Comment Organism
7 9 less than 50% of maximal activity at pH 7.0 and 9.0 Homo sapiens