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Literature summary for 3.1.26.5 extracted from

  • Pace, N.R.; Smith, D.
    Ribonuclease P: function and variation (1990), J. Biol. Chem., 265, 3587-3590.
    View publication on PubMed
Search for more literature for 3.1.26.5

Cloned(Commentary)

Cloned (Comment) Organism
gene for the protein moiety Bacillus subtilis

Inhibitors

Inhibitors Comment Organism Structure
tRNA mature tRNA is a competitive inhibitor of pre-tRNA cleavage Bacillus subtilis
tRNA
-
 Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
additional information eukaryotic cells may contain multiple RNase P activities, a nucear type as well as enzyme species in mitochondria and chloroplasts Homo sapiens
-
-
additional information eukaryotic cells may contain multiple RNase P activities, a nucear type as well as enzyme species in mitochondria and chloroplasts Saccharomyces cerevisiae
-
-
additional information eukaryotic cells may contain multiple RNase P activities, a nucear type as well as enzyme species in mitochondria and chloroplasts Xenopus laevis
-
-
additional information eukaryotic cells may contain multiple RNase P activities, a nucear type as well as enzyme species in mitochondria and chloroplasts Schizosaccharomyces pombe
-
-
nucleus
-
 Homo sapiens 5634
-
nucleus
-
 Saccharomyces cerevisiae 5634
-
nucleus
-
 Xenopus laevis 5634
-
nucleus
-
 Schizosaccharomyces pombe 5634
-

Metals/Ions

Metals/Ions Comment Organism Structure
K+
-
 Homo sapiens
K+
-
 Schizosaccharomyces pombe
K+ optimal activity at 0.3-1 M NH4Cl or KCl Bacillus subtilis
Mg2+
-
 Homo sapiens
Mg2+ optimal activity at 20-200 mM MgCl2 Bacillus subtilis
NH4+
-
 Homo sapiens
NH4+ optimal activity at 0.3-1 M NH4Cl or KCl Bacillus subtilis

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
pre-tRNA + H2O Homo sapiens
-
 tRNA + 5'-oligoribonucleotide
-
 ?
pre-tRNA + H2O Saccharomyces cerevisiae
-
 tRNA + 5'-oligoribonucleotide
-
 ?
pre-tRNA + H2O Bacillus subtilis the enzyme is responsible for the cleavage of sequences from the 5' ends of precursors of tRNAs to produce the mature 5' terminus of the tRNA molecules tRNA + 5'-oligoribonucleotide
-
 ?

Organism

Organism UniProt Comment Textmining
Bacillus subtilis
-
-
-
Homo sapiens
-
-
-
Saccharomyces cerevisiae
-
-
-
Schizosaccharomyces pombe
-
-
-
Xenopus laevis
-
-
-

Posttranslational Modification

Posttranslational Modification Comment Organism
ribonucleoprotein
-
 Homo sapiens
ribonucleoprotein
-
 Saccharomyces cerevisiae
ribonucleoprotein
-
 Schizosaccharomyces pombe
ribonucleoprotein the enzyme requires an RNA as well as a protein subunit for its in vivo activity Bacillus subtilis

Source Tissue

Source Tissue Comment Organism Textmining
HeLa cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
pre-tRNA + H2O
-
 Homo sapiens tRNA + 5'-oligoribonucleotide
-
 ?
pre-tRNA + H2O
-
 Saccharomyces cerevisiae tRNA + 5'-oligoribonucleotide
-
 ?
pre-tRNA + H2O the enzyme is responsible for the cleavage of sequences from the 5' ends of precursors of tRNAs to produce the mature 5' terminus of the tRNA molecules Bacillus subtilis tRNA + 5'-oligoribonucleotide
-
 ?
pre-tRNA precursor + H2O
-
 Homo sapiens tRNA + 5'-oligoribonucleotide
-
 ?
pre-tRNA precursor + H2O
-
 Saccharomyces cerevisiae tRNA + 5'-oligoribonucleotide
-
 ?
pre-tRNA precursor + H2O
-
 Xenopus laevis tRNA + 5'-oligoribonucleotide
-
 ?
pre-tRNA precursor + H2O
-
 Schizosaccharomyces pombe tRNA + 5'-oligoribonucleotide
-
 ?
pre-tRNA precursor + H2O the conserved sequences CCA and GUUCG, as well as the substrate bond, occur on the same face of the coaxial helix that constitutes the minimum substrate for the enzyme Bacillus subtilis tRNA + 5'-oligoribonucleotide
-
 ?