Application | Comment | Organism |
---|---|---|
additional information | RNA-directed off/on switch of RNase H activity using boronic ester formation | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
additional information | 5'-boronic acid modified oligonucleotides (ORNs) hybridized to a RNA target sequence convert RNase H into an inactivated enzyme complex. The dynamic formation of a boronate ester upon addition of a diol moiety disrupts the enzyme-inhibitor complex and reactivates RNase H. Reactivation of RNase H function can also be engineered through short RNA trimers inputs that fashion RNase H from a non-specific DNA-guided enzyme into an informational and programmable RNA-guided one. Programmable RNA recognition and cleavage, method, overview | Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | Homo sapiens | RNase H is a non-specific endonuclease which degrades selectively the RNA strand in DNA/RNA duplexes | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | O60930 | - |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | RNase H is a non-specific endonuclease which degrades selectively the RNA strand in DNA/RNA duplexes | Homo sapiens | ? | - |
? | |
additional information | RNase H activated cleavage of ORN3-ORN6 by incoming ribonucleotides | Homo sapiens | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
RNase H | - |
Homo sapiens |