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Literature summary for 3.1.26.4 extracted from

  • Patureau, B.M.; Hudson, R.H.; Damha, M.J.
    Induction of RNase H activity by arabinose-peptide nucleic acid chimeras (2007), Bioconjug. Chem., 18, 421-430.
    View publication on PubMed

Activating Compound

Activating Compound Comment Organism Structure
additional information ability of the DNA and 2'-FANA oligomers of mixed-base composition to elicit human RNase H1 degradation of complementary RNA that is either unstructured or as a hairpin, overview Homo sapiens

Metals/Ions

Metals/Ions Comment Organism Structure
Mg2+
-
Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
DNA-RNA hybrid + H2O Homo sapiens
-
DNA + 5'-phosphonucleotides
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
DNA-RNA hybrid + H2O
-
Homo sapiens DNA + 5'-phosphonucleotides
-
?
peptide nucleic acid - 2'-deoxy 2'-fluoroarabinonucleic acid hybrid + H2O chimeric oligomers possessing a single central peptide nucleic acid insert are capable of forming hybrid duplexes with complementary RNA, although with diminished thermal stability in comparison to the unmodified oligomers Homo sapiens ?
-
?
peptide nucleic acid - DNA + H2O chimeric oligomers possessing a single central peptide nucleic acid insert are capable of forming hybrid duplexes with complementary RNA, although with diminished thermal stability in comparison to the unmodified oligomers Homo sapiens ?
-
?

Synonyms

Synonyms Comment Organism
RNase H
-
Homo sapiens

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
-
assay at Homo sapiens

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.8
-
assay at Homo sapiens