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Literature summary for 3.1.26.3 extracted from

  • Le Rhun, A.; Lecrivain, A.L.; Reimegard, J.; Proux-Wera, E.; Broglia, L.; Della Beffa, C.; Charpentier, E.
    Identification of endoribonuclease specific cleavage positions reveals novel targets of RNase III in Streptococcus pyogenes (2017), Nucleic Acids Res., 45, 2329-2340 .
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.1.26.3

Cloned(Commentary)

Cloned (Comment) Organism
gene rnc Streptococcus pyogenes serotype M1

Protein Variants

Protein Variants Comment Organism
additional information construction of a complemented DELTArnc strain Streptococcus pyogenes serotype M1

Organism

Organism UniProt Comment Textmining
Streptococcus pyogenes serotype M1 P66670 and isogenic derivatives
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Streptococcus pyogenes serotype M1 SF370 (M1GAS) P66670 and isogenic derivatives
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information development of a method, called identification of specific cleavage position (ISCP), which enables the identification of direct endoribonuclease targets in vivo by comparing the 5' and 3' ends of processed transcripts between wild-type and RNase-deficient strains. The double-stranded specific RNase III in the human pathogen Streptococcus pyogenes is used as a model. Mapping of 92 specific cleavage positions (SCPs) among which, 48 are previously described and 44 are new, with the characteristic 2 nucleotides 3' overhang of RNase III. Most SCPs are located in untranslated regions of RNAs. Screening for RNase III targets using transcriptomic differential expression analysis (DEA) and comparison with the RNase III targets identified using the ISCP method. Method evaluation, overview. pre-rRNA maturation by RNase III Streptococcus pyogenes serotype M1 ?
-
 ?
additional information development of a method, called identification of specific cleavage position (ISCP), which enables the identification of direct endoribonuclease targets in vivo by comparing the 5' and 3' ends of processed transcripts between wild-type and RNase-deficient strains. The double-stranded specific RNase III in the human pathogen Streptococcus pyogenes is used as a model. Mapping of 92 specific cleavage positions (SCPs) among which, 48 are previously described and 44 are new, with the characteristic 2 nucleotides 3' overhang of RNase III. Most SCPs are located in untranslated regions of RNAs. Screening for RNase III targets using transcriptomic differential expression analysis (DEA) and comparison with the RNase III targets identified using the ISCP method. Method evaluation, overview. pre-rRNA maturation by RNase III Streptococcus pyogenes serotype M1 SF370 (M1GAS) ?
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 ?

Synonyms

Synonyms Comment Organism
RNase III
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 Streptococcus pyogenes serotype M1
rnc
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 Streptococcus pyogenes serotype M1

General Information

General Information Comment Organism
malfunction in Streptomyces pyogenes, under standard growth conditions, RNase III has a limited impact both on antisense transcripts and on global gene expression with the expression of most of the affected genes being downregulated in an RNase III deletion mutant Streptococcus pyogenes serotype M1
physiological function in Streptomyces pyogenes, under standard growth conditions, RNase III has a limited impact both on antisense transcripts and on global gene expression with the expression of most of the affected genes being downregulated in an RNase III deletion mutant. pre-rRNA maturation by RNase III. RNase III has a limited impact on gene expression regulation Streptococcus pyogenes serotype M1