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Literature summary for 3.1.26.3 extracted from

  • Dewi, D.L.; Ishii, H.; Haraguchi, N.; Nishikawa, S.; Kano, Y.; Fukusumi, T.; Ozaki, M.; Saito, T.; Sakai, D.; Satoh, T.; Doki, Y.; Mori, M.
    Dicer 1, ribonuclease type III modulates a reprogramming effect in colorectal cancer cells (2012), Int. J. Mol. Med., 29, 1060-1064.
    View publication on PubMed
Search for more literature for 3.1.26.3

Organism

Organism UniProt Comment Textmining
Homo sapiens
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-
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Source Tissue

Source Tissue Comment Organism Textmining
DLD-1 cell
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 Homo sapiens
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HCT-116 cell
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 Homo sapiens
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Synonyms

Synonyms Comment Organism
Dicer 1
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 Homo sapiens
Dicer1
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 Homo sapiens
ribonuclease type III
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 Homo sapiens

General Information

General Information Comment Organism
malfunction enzyme-deficient CRC cells show a reduced number of alkaline phosphatase-positive reprogrammed cells than wild-type cells, phenotype analysis of enzyme-deficient mutant HCT116 and DLD-1 cancer cell lines, overview. Transfection of specific transcription factors, such as Oct4, Sox2, Klf4 and c-Myc, or of miR-302s results in a considerable modulation of the malignant phenotypes of cancer cells, i.e. invasion, cell growth, tumorigenicity, and sensitivity to chemotherapeutic reagents and differentiation reagents, such as vitamins Homo sapiens
physiological function the enzyme is a critical miRNA processing enzyme, miRNAs play crucial roles in developmental processes, stress response, stem cell physiology, and diseases such as cancer Homo sapiens