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Literature summary for 3.1.26.3 extracted from

  • Georgi, S.A.; Reh, T.A.
    Dicer is required for the transition from early to late progenitor state in the developing mouse retina (2010), J. Neurosci., 30, 4048-4061.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.1.26.3

Organism

Organism UniProt Comment Textmining
Mus musculus
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 alphaPax6cre mice
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Source Tissue

Source Tissue Comment Organism Textmining
retina
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 Mus musculus
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Synonyms

Synonyms Comment Organism
Dicer
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 Mus musculus
RNase III
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 Mus musculus

General Information

General Information Comment Organism
malfunction dicer conditional knock-out retinas show developmental changes at embryonic day 16. In the absence of dicer in the embryonic retina, production of early generated cell types (ganglion and horizontal cells) is increased, and markers of late progenitors are not expressed. This phenotype persists into postnatal retina, in which the dicer-deficient progenitors fail to generate late-born cell types such as rods and Müller glia but continue to generate ganglion cells. Increase in apoptosis in dicer-deficient retinas. Most dicer-deficient cells die by adulthood. Postnatal day 5 dicer conditional knock-out retinas show a similar phenotype as that found at postnatal day 1. Select micro-RNAs are lost from dicer conditional knock-out areas at embryonic day 16 Mus musculus
physiological function dicer is necessary for the developmental change in competence of the retinal progenitor cells Mus musculus