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Literature summary for 3.1.26.13 extracted from

  • Zheng, X.; Mueller, G.A.; DeRose, E.F.; London, R.E.
    Metal and ligand binding to the HIV-RNase H active site are remotely monitored by Ile556 (2012), Nucleic Acids Res., 40, 10543-10553.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.1.26.13

Protein Variants

Protein Variants Comment Organism
H539S active site mutant Human immunodeficiency virus 1
R557S active site mutant Human immunodeficiency virus 1

Inhibitors

Inhibitors Comment Organism Structure
2-hydroxyisoquinoline-1,3(2H,4H)-dione
-
 Human immunodeficiency virus 1

Metals/Ions

Metals/Ions Comment Organism Structure
Mg2+ required Human immunodeficiency virus 1
Zn2+ optimal RT RNase H activity at about 0.025 mM Zn2+ Human immunodeficiency virus 1

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
RNA-DNA hybrid + H2O Human immunodeficiency virus 1
-
 ?
-
 ?

Organism

Organism UniProt Comment Textmining
Human immunodeficiency virus 1
-
-
-

Purification (Commentary)

Purification (Comment) Organism
HiTrap column chromatography and Superdex 200 gel filtration Human immunodeficiency virus 1

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
RNA-DNA hybrid + H2O
-
 Human immunodeficiency virus 1 ?
-
 ?

Synonyms

Synonyms Comment Organism
ribonuclease H
-
 Human immunodeficiency virus 1
RNase H
-
 Human immunodeficiency virus 1
RT RNase H reverse transcriptase contains a C-terminal ribonuclease H domain on its p66 subunit Human immunodeficiency virus 1