Inhibitors | Comment | Organism | Structure |
---|---|---|---|
1-(3-[[(4-benzyl-5-methyl-4H-1,2,4-triazol-3-yl)sulfanyl]methyl]-4-methoxyphenyl)ethanone | - |
Human immunodeficiency virus 1 | |
1-hydroxy-4-[[4-(quinolin-3-yl)phenyl]amino]pyrido[2,3-d]pyrimidin-2(1H)-one | GSK5724, exceptional RNase H inhibitory potency | Human immunodeficiency virus 1 | |
2-amino-5,6,7,8-tetrahydro-4H-cyclohepta[b]thiophene-3-carboxamide | - |
Human immunodeficiency virus 1 | |
2-hydroxy-(4H)-isoquinoline-1,3-dione | inhibits RNase H in vitro with submicromolar potency | Human immunodeficiency virus 1 | |
2-hydroxy-4-methoxycarbonylisoquinoline-1,3(2H, 4H)-dione | inhibits RNase H in vitro with nanomolar potency | Human immunodeficiency virus 1 | |
2-oxo-2-(phenylamino)ethyl dibenzylcarbamodithioate | - |
Human immunodeficiency virus 1 | |
2-[(2-bromo-5-chloro-1-benzothiophen-3-yl)methyl]-5,6-dihydroxypyrimidine-4-carboxylic acid | - |
Human immunodeficiency virus 1 | |
3'-[(E)-[2-(3,4,5-trihydroxybenzoyl)hydrazinylidene]methyl]biphenyl-4-carboxylic acid | - |
Human immunodeficiency virus 1 | |
4-([[4-benzyl-5-(thiophen-2-yl)-4H-1,2,4-triazol-3-yl]sulfanyl]methyl)pyridine | - |
Human immunodeficiency virus 1 | |
4-tert-butyl-N'-[(E)-(2-hydroxynaphthalen-1-yl)methylidene]benzohydrazide | - |
Human immunodeficiency virus 1 | |
4-[5-(benzoylamino)thien-2-yl]-2,4-dioxobutanoic acid | - |
Human immunodeficiency virus 1 | |
4-[5-(benzoylamino)thiophen-2-yl]-2,4-dioxobutanoic acid | - |
Human immunodeficiency virus 1 | |
4-[[4'-(aminomethyl)biphenyl-4-yl]methyl]-1-hydroxy-1,8-naphthyridin-2(1H)-one | - |
Human immunodeficiency virus 1 | |
6-[1-(4-fluorophenyl)methyl-1H-pyrrol-2-yl]-2,4-dioxo-5-hexenoic acid ethyl ester | i.e. RDS-1643, shows relatively weak but selective inhibitory activity against RNase H | Human immunodeficiency virus 1 | |
beta-thujaplicinol | shows submicromolar inhibitory activity against RNase H | Human immunodeficiency virus 1 | |
dihydroxybenzoyl naphthyl hydrazone | - |
Human immunodeficiency virus 1 | |
ethyl 1,4-dihydroxy-2-oxo-1,2-dihydro-1,8-naphthyridine-3-carboxylate | - |
Human immunodeficiency virus 1 | |
pyrimidinol carboxylic acid | - |
Human immunodeficiency virus 1 |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Mg2+ | two Mg2+ cations are essential for enzyme function | Human immunodeficiency virus 1 |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Human immunodeficiency virus 1 | - |
- |
- |
Synonyms | Comment | Organism |
---|---|---|
reverse transcriptase | the multifunctional enzyme has RNA and DNA dependent polymerase activity, along with ribonuclease H activity | Human immunodeficiency virus 1 |
ribonuclease H | - |
Human immunodeficiency virus 1 |
RNase H | - |
Human immunodeficiency virus 1 |
IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|
0.000003 | - |
pH and temperature not specified in the publication | Human immunodeficiency virus 1 | 1-hydroxy-4-[[4-(quinolin-3-yl)phenyl]amino]pyrido[2,3-d]pyrimidin-2(1H)-one | |
0.000045 | - |
pH and temperature not specified in the publication | Human immunodeficiency virus 1 | 4-[[4'-(aminomethyl)biphenyl-4-yl]methyl]-1-hydroxy-1,8-naphthyridin-2(1H)-one | |
0.000061 | - |
pH and temperature not specified in the publication | Human immunodeficiency virus 1 | 2-hydroxy-4-methoxycarbonylisoquinoline-1,3(2H, 4H)-dione | |
0.0001 | - |
pH and temperature not specified in the publication | Human immunodeficiency virus 1 | 3'-[(E)-[2-(3,4,5-trihydroxybenzoyl)hydrazinylidene]methyl]biphenyl-4-carboxylic acid | |
0.00011 | - |
pH and temperature not specified in the publication | Human immunodeficiency virus 1 | ethyl 1,4-dihydroxy-2-oxo-1,2-dihydro-1,8-naphthyridine-3-carboxylate | |
0.00013 | - |
pH and temperature not specified in the publication | Human immunodeficiency virus 1 | 6-[1-(4-fluorophenyl)methyl-1H-pyrrol-2-yl]-2,4-dioxo-5-hexenoic acid ethyl ester | |
0.00017 | - |
pH and temperature not specified in the publication | Human immunodeficiency virus 1 | 2-[(2-bromo-5-chloro-1-benzothiophen-3-yl)methyl]-5,6-dihydroxypyrimidine-4-carboxylic acid | |
0.0002 | - |
pH and temperature not specified in the publication | Human immunodeficiency virus 1 | 4-([[4-benzyl-5-(thiophen-2-yl)-4H-1,2,4-triazol-3-yl]sulfanyl]methyl)pyridine | |
0.0008 | - |
pH and temperature not specified in the publication | Human immunodeficiency virus 1 | 1-(3-[[(4-benzyl-5-methyl-4H-1,2,4-triazol-3-yl)sulfanyl]methyl]-4-methoxyphenyl)ethanone | |
0.0019 | - |
pH and temperature not specified in the publication | Human immunodeficiency virus 1 | 2-oxo-2-(phenylamino)ethyl dibenzylcarbamodithioate | |
0.002 | - |
pH and temperature not specified in the publication | Human immunodeficiency virus 1 | 2-amino-5,6,7,8-tetrahydro-4H-cyclohepta[b]thiophene-3-carboxamide | |
0.0032 | - |
pH and temperature not specified in the publication | Human immunodeficiency virus 1 | 4-[5-(benzoylamino)thiophen-2-yl]-2,4-dioxobutanoic acid | |
0.0035 | - |
pH and temperature not specified in the publication | Human immunodeficiency virus 1 | 4-tert-butyl-N'-[(E)-(2-hydroxynaphthalen-1-yl)methylidene]benzohydrazide |
General Information | Comment | Organism |
---|---|---|
physiological function | RNase H activity is essential for virus infectivity | Human immunodeficiency virus 1 |