Inhibitors | Comment | Organism | Structure |
---|---|---|---|
2-hydroxy-4-(2-phenyl)ethylisoquinoline-1,3(2H,4H)-dione | enol-form | Human Immunodeficiency Virus | |
2-hydroxy-4-(3-phenyl)propylisoquinoline-1,3(2H,4H)-dione | mixture of th mixed ketoenol forms or keto-form | Human Immunodeficiency Virus | |
2-hydroxy-4-(4-methylbenzyl)isoquinoline-1,3(2H,4H)-dione | mixture of th mixed ketoenol forms or keto-form | Human Immunodeficiency Virus | |
2-hydroxy-4-(4-trifluoromethylbenzyl)isoquinoline-1,3(2H-4H)-dione | keto-form | Human Immunodeficiency Virus | |
2-hydroxy-4-butylisoquinoline-1,3(2H,4H)-dione | mixture of th mixed ketoenol forms or keto-form | Human Immunodeficiency Virus | |
2-hydroxy-4-ethylisoquinoline-1,3(2H,4H)-dione | - |
Human Immunodeficiency Virus | |
2-hydroxy-4-isopropylisoquinoline-1,3(2H,4H)-dione | - |
Human Immunodeficiency Virus | |
2-hydroxy-4-methylisoquinoline-1,3(2H,4H)-dione | - |
Human Immunodeficiency Virus | |
2-hydroxy-4-pentylisoquinoline-1,3(2H,4H)-dione | - |
Human Immunodeficiency Virus | |
2-hydroxy-4-propylisoquinoline-1,3(2H,4H)-dione | - |
Human Immunodeficiency Virus | |
2-hydroxyisoquinoline-1,3(2H,4H)-dione | - |
Human Immunodeficiency Virus | |
4-benzyl-2-hydroxy-isoquinoline-1,3(2H,4H)-dione | keto-form; mixture of th mixed ketoenol forms | Human Immunodeficiency Virus | |
4-heptyl-2-hydroxy-isoquinoline-1,3(2H,4H)-dione | enol form | Human Immunodeficiency Virus | |
4-hexyl-2-hydroxy-isoquinoline-1,3(2H,4H)-dione | keto-form; mixture of th mixed ketoenol forms | Human Immunodeficiency Virus | |
additional information | synthesis of 2-hydroxyisoquinoline-1,3(2H,4H)-dione derivatives as inhibitors of the RNase H activity of the reverse transcriptase of HIV-1, docking, study, overview. No inhibition by keto-5i and 5l | Human Immunodeficiency Virus |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Human Immunodeficiency Virus | - |
HIV-1 | - |
Synonyms | Comment | Organism |
---|---|---|
ribonuclease H | - |
Human Immunodeficiency Virus |
RNase H | - |
Human Immunodeficiency Virus |
IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|
0.0059 | - |
pH 8.0, 37°C | Human Immunodeficiency Virus | 2-hydroxyisoquinoline-1,3(2H,4H)-dione | |
0.0078 | - |
pH 8.0, 37°C | Human Immunodeficiency Virus | 4-hexyl-2-hydroxy-isoquinoline-1,3(2H,4H)-dione | |
0.0132 | - |
pH 8.0, 37°C | Human Immunodeficiency Virus | 2-hydroxy-4-butylisoquinoline-1,3(2H,4H)-dione | |
0.0149 | - |
pH 8.0, 37°C | Human Immunodeficiency Virus | 4-benzyl-2-hydroxy-isoquinoline-1,3(2H,4H)-dione | |
0.0185 | - |
pH 8.0, 37°C | Human Immunodeficiency Virus | 2-hydroxy-4-isopropylisoquinoline-1,3(2H,4H)-dione | |
0.0336 | - |
pH 8.0, 37°C | Human Immunodeficiency Virus | 2-hydroxy-4-pentylisoquinoline-1,3(2H,4H)-dione | |
0.038 | - |
pH 8.0, 37°C | Human Immunodeficiency Virus | 4-hexyl-2-hydroxy-isoquinoline-1,3(2H,4H)-dione | |
0.0388 | - |
pH 8.0, 37°C | Human Immunodeficiency Virus | 2-hydroxy-4-ethylisoquinoline-1,3(2H,4H)-dione | |
0.0427 | - |
pH 8.0, 37°C | Human Immunodeficiency Virus | 2-hydroxy-4-(4-trifluoromethylbenzyl)isoquinoline-1,3(2H-4H)-dione | |
0.045 | - |
pH 8.0, 37°C | Human Immunodeficiency Virus | 4-heptyl-2-hydroxy-isoquinoline-1,3(2H,4H)-dione | |
0.0468 | - |
pH 8.0, 37°C | Human Immunodeficiency Virus | 2-hydroxy-4-propylisoquinoline-1,3(2H,4H)-dione | |
0.0668 | - |
pH 8.0, 37°C | Human Immunodeficiency Virus | 2-hydroxy-4-(3-phenyl)propylisoquinoline-1,3(2H,4H)-dione | |
0.07 | - |
pH 8.0, 37°C | Human Immunodeficiency Virus | 2-hydroxy-4-methylisoquinoline-1,3(2H,4H)-dione | |
0.08 | - |
pH 8.0, 37°C | Human Immunodeficiency Virus | 2-hydroxy-4-(4-methylbenzyl)isoquinoline-1,3(2H,4H)-dione |