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Literature summary for 3.1.26.13 extracted from

  • Kirschberg, T.A.; Balakrishnan, M.; Squires, N.H.; Barnes, T.; Brendza, K.M.; Chen, X.; Eisenberg, E.J.; Jin, W.; Kutty, N.; Leavitt, S.; Liclican, A.; Liu, Q.; Liu, X.; Mak, J.; Perry, J.K.; Wang, M.; Watkins, W.J.; Lansdon, E.B.
    RNase H active site inhibitors of human immunodeficiency virus type 1 reverse transcriptase: design, biochemical activity, and structural information (2009), J. Med. Chem., 52, 5781-5784.
    View publication on PubMed
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Inhibitors

Inhibitors Comment Organism Structure
2,7-dihydroxy-4-(propan-2-yl)cyclohepta-2,4,6-trien-1-one inhibition of enzymatic activity, but no antiviral effect Human immunodeficiency virus 1
2-(3,4-dichlorobenzyl)-5,6-dihydroxypyrimidine-4-carboxylic acid inhibition of enzymatic activity, but no antiviral effect Human immunodeficiency virus 1
2-(3-bromo-4-methoxybenzyl)-5,6-dihydroxypyrimidine-4-carboxylic acid inhibition of enzymatic activity, but no antiviral effect Human immunodeficiency virus 1
2-hydroxyisoquinoline-1,3(2H,4H)-dione inhibition of enzymatic activity, but no antiviral effect Human immunodeficiency virus 1

Metals/Ions

Metals/Ions Comment Organism Structure
Mn2+ solid state structure, two Mn2+ ions bound to the RNase H active site Human immunodeficiency virus 1

Organism

Organism UniProt Comment Textmining
Human immunodeficiency virus 1
-
-
-

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.00012
-
-
 Human immunodeficiency virus 1 2-hydroxyisoquinoline-1,3(2H,4H)-dione
0.0006
-
-
 Human immunodeficiency virus 1 2,7-dihydroxy-4-(propan-2-yl)cyclohepta-2,4,6-trien-1-one
0.0009
-
-
 Human immunodeficiency virus 1 2-(3-bromo-4-methoxybenzyl)-5,6-dihydroxypyrimidine-4-carboxylic acid
0.0012
-
-
 Human immunodeficiency virus 1 2-(3,4-dichlorobenzyl)-5,6-dihydroxypyrimidine-4-carboxylic acid