Literature summary for 3.1.26.13 extracted from

Davis, W.R.; Tomsho, J.; Nikam, S.; Cook, E.M.; Somand, D.; Peliska, J.A.
Inhibition of HIV-1 reverse transcriptase-catalyzed DNA strand transfer reactions by 4-chlorophenylhydrazone of mesoxalic acid (2000), Biochemistry, 39, 14279-14291.

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Inhibitors

Inhibitors	Comment	Organism	Structure
[2-(4-chlorophenyl)hydrazinylidene]propanedioic acid	inhibits RNase H activity, does not significantly affect DNA polymerase activity of reverse transcriptase. In the absence of DNA synthesis, [2-(4-chlorophenyl)hydrazinylidene]propanedioic acid interferes with the translocation, or repositioning, of the enzyme on the RNA-DNA template duplex. Inhibitor is highly specific for human immunodeficiency virus. The dicarboxylic acid moiety is essential for activity, and Mg2+ chelates directly with a Kd value of 2.4 mM	Human immunodeficiency virus 1

Organism

Organism	UniProt	Comment	Textmining
Human immunodeficiency virus 1	-	-	-

IC50 Value

IC50 Value	IC50 Value Maximum	Comment	Organism	Inhibitor	Structure
0.0022	-	pH 7.6, 37°C	Human immunodeficiency virus 1	[2-(4-chlorophenyl)hydrazinylidene]propanedioic acid

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Release 2023.1 (January 2023)