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Literature summary for 3.1.26.11 extracted from
- Mode of action of RNase BN/RNase Z on tRNA precursors: RNase BN does not remove the CCA sequence from tRNA (2010), J. Biol. Chem., 285, 22874-22881.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| additional information | presence of a 3'-terminal CCA sequence inhibits RNase BN | Escherichia coli |
Metals/Ions
| Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|
| Mg2+ | required | Escherichia coli |  |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Escherichia coli | - |
- |
- |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| 3'-tRNase | - |
Escherichia coli |
| RNase Z | - |
Escherichia coli |
Temperature Optimum [°C]
| Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
|---|---|---|---|
| 37 | - |
assay at | Escherichia coli |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 6.5 | 7.5 | assay at | Escherichia coli |
General Information
| General Information | Comment | Organism |
|---|---|---|
| physiological function | in addition to tRNase Z, RNase BN of Escherichia coli can act on tRNA precursors containing or lacking a CCA sequence and that it can do so as either an exoribonuclease or an endoribonuclease, overview. Addition of Co2+ results in higher activity and predominantly exoribonucleolytic activity, whereas in the presence of Mg2+ RNase BN is primarily an endoribonuclease. Certain tRNA precursors are extremely poor substrates, overview | Escherichia coli |
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