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Literature summary for 3.1.26.11 extracted from

  • Elbarbary, R.A.; Takaku, H.; Uchiumi, N.; Tamiya, H.; Abe, M.; Nishida, H.; Nashimoto, M.
    Human cytosolic tRNase ZL can downregulate gene expression through miRNA (2009), FEBS Lett., 583, 3241-3246.
    View publication on PubMed

Cloned(Commentary)

Cloned (Comment) Organism
293 and HeLa cells co-transfected with the tRNase ZL expression plasmid (+ZL), the tRNase ZS expression plasmid (+ZS), the tRNase ZL siRNA (-ZL), or the Ago2 siRNAs Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
cytosol
-
Homo sapiens 5829
-

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Synonyms

Synonyms Comment Organism
long form of tRNase Z
-
Homo sapiens
tRNase ZL
-
Homo sapiens

General Information

General Information Comment Organism
physiological function cytosolic tRNase ZL modulates gene expression through a subset of microRNAs in the cells. MiR-103 can form a hook structure to guide target RNA cleavage by cytosolic tRNase ZL in vitro. MiR-103 downregulates gene expression through directing mRNA cleavage by tRNase ZL Homo sapiens