Literature summary for 3.1.25.1 extracted from

Hacker, E.; Muller, H.K.; Hayward, N.; Fahey, P.; Walker, G.
Enhancement of DNA repair using topical T4 endonuclease V does not inhibit melanoma formation in Cdk4(R24C/R24C)/Tyr-Nras(Q61K) mice following neonatal UVR (2010), Pigment Cell Melanoma Res., 23, 121-128.

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Organism

Organism	UniProt	Comment	Textmining
Mus musculus	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
melanocyte	-	Mus musculus	-
skin	-	Mus musculus	-

Synonyms

Synonyms	Comment	Organism
More	Dimericine	Mus musculus
T4 endonuclease V	-	Mus musculus

General Information

General Information	Comment	Organism
additional information	treatment of Cdk4R24C/R24C/NrasQ61K mice topically with the T4 endonuclease V DNA repair enzyme immediately prior to neonatal ultraviolet radiation exposure has a powerful effect in exacerbating melanoma development in the mouse model, overview. Dimericine reduces the incidence of basal-cell and squamous cell carcinoma. No difference in penetrance or age of onset of melanoma after neonatal UVR between Dimericine-treated and control animals, although the drug reduces DNA damage and cellular proliferation in the skin. Proliferation of melanocytes is inhibited by Dimericine treatment and reduces the level of DNA damage following UVR exposure	Mus musculus
physiological function	the T4 endonuclease V is a DNA repair enzyme	Mus musculus

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Release 2023.1 (January 2023)