BRENDA - Enzyme Database
show all sequences of 3.1.25.1

Purification and properties of a pyrimidine dimer-specific endonuclease from E. coli infected with bacteriophage T4

Friedberg, E.C.; Ganesan, A.K.; Seawell, P.C.; Methods Enzymol. 65, 191-201 (1980) View publication on PubMed

Data extracted from this reference:

Inhibitors
Inhibitors
Commentary
Organism
Structure
p-chloromercuribenzoate
70-80% inhibition in presence of 0.0004 M
Escherichia virus T4
p-chloromercuriphenylsulfonic acid
20-25% inhibition in presence of 0.0001 M
Escherichia virus T4
Metals/Ions
Metals/Ions
Commentary
Organism
Structure
Mg2+
slight stimulation
Escherichia virus T4
Mn2+
slight stimulation
Escherichia virus T4
Molecular Weight [Da]
Molecular Weight [Da]
Molecular Weight Maximum [Da]
Commentary
Organism
18000
-
PAGE, gel filtration
Escherichia virus T4
Natural Substrates/ Products (Substrates)
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
ID
DNA + H2O
Escherichia virus T4
-
?
-
-
?
Organism
Organism
UniProt
Commentary
Textmining
Escherichia virus T4
-
-
-
Purification (Commentary)
Purification (Commentary)
Organism
100-300fold, extensive purification, attempts to concentrate the enzyme preparation by Aquacide II or Sephadex G50 powder results in loss of activity, UV-DNA-cellulose chromatography, hydroxyapatite chromatography, gel filtration through Sephadex or CM-Sephadex as well as sedimentation in sucrose density gradients results in loss of activity if used after phosphocellulose chromatography, enzyme is more stable in fractions containing large amounts of protein like bovine serum albumin
Escherichia virus T4
Source Tissue
Source Tissue
Commentary
Organism
Textmining
infected cell
T4 infected
Escherichia virus T4
-
Storage Stability
Storage Stability
Organism
-12°C, in 12% glycerol, inactivates the enzyme
Escherichia virus T4
4°C, in 50 mM Tris-HCl, pH 7.5, containing 10% ethylene glycol or 3% polyethylene glycol, storage for several months
Escherichia virus T4
freezing, leads to inactivation
Escherichia virus T4
Substrates and Products (Substrate)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
Substrate Product ID
ColE1 DNA + H2O
UV-irradiated, superhelical
170712
Escherichia virus T4
oligonucleotides
-
170712
Escherichia virus T4
?
DNA + H2O
-
170712
Escherichia virus T4
?
-
-
-
?
E. coli DNA + H2O
single-stranded DNA
170712
Escherichia virus T4
oligonucleotides
-
170712
Escherichia virus T4
?
E. coli DNA + H2O
UV-irradiated dsDNA
170712
Escherichia virus T4
oligonucleotides
-
170712
Escherichia virus T4
?
glycosylated DNA + H2O
UV-irradiated, cleaves also nonglycosylated DNA
170712
Escherichia virus T4
oligonucleotides
-
170712
Escherichia virus T4
?
additional information
not: 5-thyminyl-5,6-dihydrothymine-containing DNA
170712
Escherichia virus T4
?
-
-
-
?
additional information
not: DNA exposed to ionizing radiation, methyl methane sulfonate, nitrogen mustard, mitomycin C, 4-nitroquinoline-1-oxide
170712
Escherichia virus T4
?
-
-
-
?
PBS1 DNA
UV irradiated, contains uracil instead of thymine
170712
Escherichia virus T4
oligonucleotides
-
170712
Escherichia virus T4
?
SPO1 DNA
UV irradiated, contains 5-hydroxymethyluracil instead of thymine
170712
Escherichia virus T4
oligonucleotides
-
170712
Escherichia virus T4
?
superhelical DNA + H2O
UV-irradiated, cleaves also linear DNA
170712
Escherichia virus T4
oligonucleotides
-
170712
Escherichia virus T4
?
Inhibitors (protein specific)
Inhibitors
Commentary
Organism
Structure
p-chloromercuribenzoate
70-80% inhibition in presence of 0.0004 M
Escherichia virus T4
p-chloromercuriphenylsulfonic acid
20-25% inhibition in presence of 0.0001 M
Escherichia virus T4
Metals/Ions (protein specific)
Metals/Ions
Commentary
Organism
Structure
Mg2+
slight stimulation
Escherichia virus T4
Mn2+
slight stimulation
Escherichia virus T4
Molecular Weight [Da] (protein specific)
Molecular Weight [Da]
Molecular Weight Maximum [Da]
Commentary
Organism
18000
-
PAGE, gel filtration
Escherichia virus T4
Natural Substrates/ Products (Substrates) (protein specific)
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
ID
DNA + H2O
Escherichia virus T4
-
?
-
-
?
Purification (Commentary) (protein specific)
Commentary
Organism
100-300fold, extensive purification, attempts to concentrate the enzyme preparation by Aquacide II or Sephadex G50 powder results in loss of activity, UV-DNA-cellulose chromatography, hydroxyapatite chromatography, gel filtration through Sephadex or CM-Sephadex as well as sedimentation in sucrose density gradients results in loss of activity if used after phosphocellulose chromatography, enzyme is more stable in fractions containing large amounts of protein like bovine serum albumin
Escherichia virus T4
Source Tissue (protein specific)
Source Tissue
Commentary
Organism
Textmining
infected cell
T4 infected
Escherichia virus T4
-
Storage Stability (protein specific)
Storage Stability
Organism
-12°C, in 12% glycerol, inactivates the enzyme
Escherichia virus T4
4°C, in 50 mM Tris-HCl, pH 7.5, containing 10% ethylene glycol or 3% polyethylene glycol, storage for several months
Escherichia virus T4
freezing, leads to inactivation
Escherichia virus T4
Substrates and Products (Substrate) (protein specific)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
ID
ColE1 DNA + H2O
UV-irradiated, superhelical
170712
Escherichia virus T4
oligonucleotides
-
170712
Escherichia virus T4
?
DNA + H2O
-
170712
Escherichia virus T4
?
-
-
-
?
E. coli DNA + H2O
single-stranded DNA
170712
Escherichia virus T4
oligonucleotides
-
170712
Escherichia virus T4
?
E. coli DNA + H2O
UV-irradiated dsDNA
170712
Escherichia virus T4
oligonucleotides
-
170712
Escherichia virus T4
?
glycosylated DNA + H2O
UV-irradiated, cleaves also nonglycosylated DNA
170712
Escherichia virus T4
oligonucleotides
-
170712
Escherichia virus T4
?
additional information
not: 5-thyminyl-5,6-dihydrothymine-containing DNA
170712
Escherichia virus T4
?
-
-
-
?
additional information
not: DNA exposed to ionizing radiation, methyl methane sulfonate, nitrogen mustard, mitomycin C, 4-nitroquinoline-1-oxide
170712
Escherichia virus T4
?
-
-
-
?
PBS1 DNA
UV irradiated, contains uracil instead of thymine
170712
Escherichia virus T4
oligonucleotides
-
170712
Escherichia virus T4
?
SPO1 DNA
UV irradiated, contains 5-hydroxymethyluracil instead of thymine
170712
Escherichia virus T4
oligonucleotides
-
170712
Escherichia virus T4
?
superhelical DNA + H2O
UV-irradiated, cleaves also linear DNA
170712
Escherichia virus T4
oligonucleotides
-
170712
Escherichia virus T4
?
Other publictions for EC 3.1.25.1
No.
1st author
Pub Med
title
organims
journal
volume
pages
year
Activating Compound
Application
Cloned(Commentary)
Crystallization (Commentary)
Protein Variants
General Stability
Inhibitors
KM Value [mM]
Localization
Metals/Ions
Molecular Weight [Da]
Natural Substrates/ Products (Substrates)
Organic Solvent Stability
Organism
Oxidation Stability
Posttranslational Modification
Purification (Commentary)
Reaction
Renatured (Commentary)
Source Tissue
Specific Activity [micromol/min/mg]
Storage Stability
Substrates and Products (Substrate)
Subunits
Synonyms
Temperature Optimum [°C]
Temperature Range [°C]
Temperature Stability [°C]
Turnover Number [1/s]
pH Optimum
pH Range
pH Stability
Cofactor
Ki Value [mM]
pI Value
IC50 Value
Activating Compound (protein specific)
Application (protein specific)
Cloned(Commentary) (protein specific)
Cofactor (protein specific)
Crystallization (Commentary) (protein specific)
Engineering (protein specific)
General Stability (protein specific)
IC50 Value (protein specific)
Inhibitors (protein specific)
Ki Value [mM] (protein specific)
KM Value [mM] (protein specific)
Localization (protein specific)
Metals/Ions (protein specific)
Molecular Weight [Da] (protein specific)
Natural Substrates/ Products (Substrates) (protein specific)
Organic Solvent Stability (protein specific)
Oxidation Stability (protein specific)
Posttranslational Modification (protein specific)
Purification (Commentary) (protein specific)
Renatured (Commentary) (protein specific)
Source Tissue (protein specific)
Specific Activity [micromol/min/mg] (protein specific)
Storage Stability (protein specific)
Substrates and Products (Substrate) (protein specific)
Subunits (protein specific)
Temperature Optimum [°C] (protein specific)
Temperature Range [°C] (protein specific)
Temperature Stability [°C] (protein specific)
Turnover Number [1/s] (protein specific)
pH Optimum (protein specific)
pH Range (protein specific)
pH Stability (protein specific)
pI Value (protein specific)
Expression
General Information
General Information (protein specific)
Expression (protein specific)
kcat/KM [mM/s]
kcat/KM [mM/s] (protein specific)
710256
Hacker
Enhancement of DNA repair usin ...
Mus musculus
Pigment Cell Melanoma Res.
23
121-128
2010
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10
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2
2
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-
691338
Jiang
UVA generates pyrimidine dimer ...
Escherichia coli
Biophys. J.
96
1151-1158
2009
-
1
-
-
-
-
-
-
-
-
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4
-
4
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1
1
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4
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1
1
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1
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4
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1
1
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4
-
1
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663864
Kim Sang
Characterization of a wide ran ...
Homo sapiens, Mus musculus
Biochem. Biophys. Res. Commun.
328
962-967
2005
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-
1
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3
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2
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2
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2
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2
2
2
6
2
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2
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2
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1
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3
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2
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2
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2
2
2
6
2
2
-
2
-
2
2
-
-
-
-
-
-
-
-
664093
Minko
Initiation of repair of DNA-po ...
[Bacillus] caldotenax, Thermotoga maritima
Biochemistry
44
3000-3009
2005
-
-
2
-
-
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2
-
2
-
4
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1
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4
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5
2
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2
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2
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2
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2
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1
-
4
-
2
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-
-
2
-
-
-
-
-
-
-
-
-
664112
Feng
Active site plasticity of endo ...
Salmonella enterica subsp. enterica serovar Typhimurium, Salmonella enterica subsp. enterica serovar Typhimurium 14028
Biochemistry
44
675-683
2005
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1
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1
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4
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2
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2
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1
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6
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2
1
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6
-
1
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1
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-
664594
Yang
Recognition and incision of ga ...
Escherichia coli
Chem. Res. Toxicol.
18
1339-1346
2005
-
-
1
-
-
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-
1
-
2
-
1
-
2
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1
1
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5
-
4
1
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1
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1
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1
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2
-
1
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1
-
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-
-
5
-
1
-
-
-
1
-
-
-
-
-
-
-
-
-
666546
Kuchel
Cyclobutane pyrimidine dimer f ...
Escherichia virus T4
Photochem. Photobiol. Sci.
4
577-582
2005
-
-
-
-
-
-
-
-
1
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-
1
-
5
-
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2
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3
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1
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1
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2
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-
-
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-
-
-
-
656881
Takasawa
Chemical synthesis and transle ...
Escherichia virus T4
Nucleic Acids Res.
32
1738-1745
2004
-
-
-
-
-
-
-
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-
1
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2
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2
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2
1
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1
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1
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-
2
-
1
-
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-
1
-
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-
-
-
656151
Ahn
Interaction of T4 endonuclease ...
Escherichia virus T4
J. Biol. Chem.
278
30985-30992
2003
-
-
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1
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1
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1
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2
1
2
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1
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2
1
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-
656845
Yarosh
Enhanced DNA repair of cyclobu ...
Escherichia virus T4
Mutat. Res.
509
221-226
2002
-
2
-
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-
-
-
-
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-
1
-
3
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2
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1
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2
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2
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656844
Morikawa
Three-dimensional structural v ...
Escherichia virus T4
Mutat. Res.
460
257-275
2000
-
-
1
1
3
-
-
-
-
-
-
1
-
7
-
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1
1
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2
1
4
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1
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1
3
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1
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1
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2
1
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-
-
-
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170716
Shiota
UV endonuclease of Micrococcus ...
Micrococcus luteus
Proc. Natl. Acad. Sci. USA
94
593-598
1997
-
-
1
-
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-
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2
1
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1
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1
1
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1
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2
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170713
Valerie
Replacing tryptophan-128 of T4 ...
Escherichia virus T4
Nucleic Acids Res.
23
3764-3770
1995
-
-
-
-
-
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-
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1
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9
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1
2
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1
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170717
Piersen
Purification and cloning of Mi ...
Micrococcus luteus
J. Biol. Chem.
270
23475-23484
1995
-
-
1
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2
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1
1
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11
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1
3
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3
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1
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170714
Latham
T4 endonuclease V, perspective ...
Escherichia virus T4
Ann. N. Y. Acad. Sci.
726
181-197
1994
-
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1
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17
-
4
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1
1
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1
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1
1
6
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2
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2
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17
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4
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1
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1
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2
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2
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170715
Kibitel
Enhancment of ultraviolet-DNA ...
Escherichia virus T4
Photochem. Photobiol.
54
753-760
1991
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1
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1
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7
-
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2
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1
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1
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-
170703
Ishida
In vitro and in vivo activitie ...
Escherichia virus T4
Biochemistry
29
3817-3821
1990
-
-
-
-
8
1
-
1
-
-
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1
-
9
-
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1
2
1
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-
3
-
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2
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8
1
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1
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1
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1
1
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3
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2
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170700
Dowd
Site-directed mutagenesis of t ...
Escherichia virus T4
Biochemistry
28
8699-8705
1989
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1
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6
-
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1
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7
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3
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1
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1
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6
-
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1
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1
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170702
Inaoka
Affinity of single- or double- ...
Escherichia virus T4
J. Biol. Chem.
264
2609-2614
1989
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-
1
-
-
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2
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1
1
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3
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1
1
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-
4
-
-
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-
-
2
2
-
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-
-
-
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-
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1
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-
-
-
-
-
-
2
-
-
1
1
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-
1
-
-
-
-
4
-
-
-
-
2
2
-
-
-
-
-
-
-
-
-
170697
Recinos
Site-directed mutagenesis of t ...
Escherichia virus T4
Biochemistry
27
1832-1838
1988
-
-
1
-
3
-
-
-
-
-
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1
-
7
-
-
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2
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-
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1
4
-
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1
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3
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1
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-
-
1
4
-
-
-
-
-
-
-
-
-
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-
170698
Stump
Site-directed mutagenesis of t ...
Escherichia virus T4
Biochemistry
27
1839-1843
1988
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1
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2
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1
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3
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1
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3
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1
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2
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1
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3
-
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-
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-
170699
Morikawa
Preliminary crystallographic s ...
Escherichia virus T4
J. Mol. Biol.
202
683-684
1988
-
-
-
1
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-
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-
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1
1
1
4
-
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1
1
-
1
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1
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-
-
-
-
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-
1
-
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-
1
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-
-
-
-
-
-
1
1
1
-
-
1
-
1
-
-
1
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
170701
Gruskin
Molecular analysis of plasmid ...
Escherichia virus T4
J. Biol. Chem.
263
12728-12737
1988
-
-
-
-
-
-
-
-
-
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1
-
3
-
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-
3
-
1
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2
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-
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-
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-
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-
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-
1
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1
-
-
2
-
-
-
-
-
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-
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-
170694
Nakabeppu
Purification and characterizat ...
Escherichia virus T4
J. Biol. Chem.
257
2556-2562
1982
-
-
-
-
-
-
1
-
-
2
1
1
-
5
-
-
1
1
-
1
1
1
2
-
-
-
-
-
-
3
-
-
-
-
-
-
-
-
-
-
-
-
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-
1
-
-
-
2
1
1
-
-
-
1
-
1
1
1
2
-
-
-
-
-
3
-
-
-
-
-
-
-
-
-
170695
Nakatsu
Action of T4 endonuclease V on ...
Escherichia virus T4
J. Biochem.
91
2057-2065
1982
-
-
-
-
-
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2
-
-
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-
1
-
1
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1
2
-
1
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3
-
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-
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2
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1
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1
-
1
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3
-
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-
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-
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-
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-
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170706
Nakabeppu
Physical association of pyrimi ...
Escherichia virus T4
Proc. Natl. Acad. Sci. USA
78
2742-2746
1981
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1
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1
1
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5
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1
2
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4
-
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-
2
-
2
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-
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-
-
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1
-
-
-
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-
-
-
-
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-
1
1
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-
1
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-
-
4
-
-
-
2
-
2
-
-
-
-
-
-
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-
170711
Riazuddin
Purification and properties of ...
Micrococcus luteus
Methods Enzymol.
65
185-191
1980
2
-
-
-
-
-
3
-
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1
-
1
-
1
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4
-
-
1
1
4
-
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-
-
1
-
1
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-
-
-
-
-
2
-
-
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-
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-
-
3
-
-
-
1
-
1
-
-
-
-
-
-
1
1
4
-
-
-
1
-
1
-
-
-
-
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-
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170712
Friedberg
Purification and properties of ...
Escherichia virus T4
Methods Enzymol.
65
191-201
1980
-
-
-
-
-
-
2
-
-
2
1
1
-
1
-
-
1
-
-
1
-
3
10
-
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-
-
-
-
-
-
-
-
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-
-
-
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-
2
-
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2
1
1
-
-
-
1
-
1
-
3
10
-
-
-
-
-
-
-
-
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-
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-
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170704
Makino
Action of T4 endonuclease V on ...
Escherichia virus T4
J. Biochem.
82
1567-1573
1977
-
-
-
-
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1
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5
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1
1
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2
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5
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1
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1
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2
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5
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-
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-
-
-
-
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-
-
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-
170707
Riazuddin
Micrococcus luteus correndonuc ...
Micrococcus luteus
J. Biol. Chem.
252
6280-6286
1977
3
-
-
-
-
-
6
-
-
3
1
1
-
2
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-
1
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-
-
1
3
4
-
-
-
-
1
-
1
1
-
-
-
-
-
3
-
-
-
-
-
-
-
6
-
-
-
3
1
1
-
-
-
1
-
-
1
3
4
-
-
-
1
-
1
1
-
-
-
-
-
-
-
-
170708
Riazuddin
Micrococcus luteus correndonuc ...
Micrococcus luteus
J. Biol. Chem.
252
6287-6293
1977
-
-
-
-
-
-
-
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1
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1
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3
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7
-
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1
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7
-
-
-
-
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-
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-
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-
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-
170709
Riazuddin
Micrococcus luteus correndonuc ...
Micrococcus luteus
J. Biol. Chem.
252
6294-6298
1977
-
-
-
-
-
-
-
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1
-
1
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1
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2
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1
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2
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170705
Sato
Studies on temperature-depende ...
Escherichia virus T4
J. Mol. Biol.
102
15-26
1976
-
-
-
-
-
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1
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3
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1
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2
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1
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2
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1
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1
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2
-
1
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2
-
-
-
-
-
-
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-
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-
170710
Braun
Enzymatic repair of DNA: Sites ...
Escherichia coli
Biochemistry
15
4116-4120
1976
-
-
-
-
-
-
-
-
-
-
-
1
-
1
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1
1
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1
1
3
-
-
-
-
-
-
-
-
-
-
-
-
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-
-
-
-
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-
-
1
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1
-
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1
1
3
-
-
-
-
-
-
-
-
-
-
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-
-
170696
Minton
The ultraviolet endonuclease o ...
Escherichia virus T4
J. Biol. Chem.
250
2823-2829
1975
-
-
-
-
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-
1
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2
1
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1
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1
1
-
-
-
1
5
-
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-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
2
1
-
-
-
1
-
-
-
1
5
-
-
-
-
-
1
-
-
-
-
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-
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-
-