Literature summary for 3.1.22.1 extracted from

Fombonne, J.; Padron, L.; Enjalbert, A.; Krantic, S.; Torriglia, A.
A novel paraptosis pathway involving LEI/L-DNaseII for EGF-induced cell death in somato-lactotrope pituitary cells (2006), Apoptosis, 11, 367-375.

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Application

Application	Comment	Organism
medicine	epidermal growth factor triggers a cleavage of Leukocyte Elastase Inhibitor precursor into L-DNase II, its subsequent enzymatic activation and nuclear translocation. Epidermal growth factor-induced cell death can be blocked by paraptosis inhibitor AIP-1/alix	Rattus norvegicus

Organism

Organism	UniProt	Comment	Textmining
Rattus norvegicus	-	-	-

Posttranslational Modification

Posttranslational Modification	Comment	Organism
proteolytic modification	epidermal growth factor triggers a cleavage of Leukocyte Elastase Inhibitor precursor into L-DNase II, its subsequent enzymatic activation and nuclear translocation	Rattus norvegicus

Source Tissue

Source Tissue	Comment	Organism	Textmining
GH4-C1 cell	somato-lactotrope cell	Rattus norvegicus	-

Synonyms

Synonyms	Comment	Organism
LEI	-	Rattus norvegicus

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Release 2023.1 (January 2023)