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Literature summary for 3.1.22.1 extracted from

  • Kawane, K.; Fukuyama, H.; Kondoh, G.; Takeda, J.; Ohsawa, Y.; Uchiyama, Y.; Nagata, S.
    Requirement of DNase II for definitive erythropoiesis in the mouse fetal liver (2001), Science, 292, 1546-1549.
    View publication on PubMed
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Cloned(Commentary)

Cloned (Comment) Organism
the subsequent targeted disruption of the DNase II gene confirms the requirement of DNase II activity within phagocytic cells Mus musculus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
DNA + H2O Mus musculus the enzyme in macrophages appears to be responsible for destroying the nuclear DNA expelled from erythroid precursor cells 3'-phosphooligonucleotides + 5'-hydroxyoligonucleotides
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 ?

Organism

Organism UniProt Comment Textmining
Mus musculus
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-
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Source Tissue

Source Tissue Comment Organism Textmining
embryo
-
 Mus musculus
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liver the enzyme gene is expressed in the fetal liver of the wild-type and DNase II+/- embryos, but not in the DNase II-/- liver Mus musculus
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macrophage
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 Mus musculus
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
DNA + H2O
-
 Mus musculus 3'-phosphooligonucleotides + 5'-hydroxyoligonucleotides
-
 ?
DNA + H2O the enzyme in macrophages appears to be responsible for destroying the nuclear DNA expelled from erythroid precursor cells Mus musculus 3'-phosphooligonucleotides + 5'-hydroxyoligonucleotides
-
 ?