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Literature summary for 3.1.22.1 extracted from

  • Wu, Y.C.; Stanfield, G.M.; Horvitz, H.R.
    NUC-1, a caenorhabditis elegans DNase II homolog, functions in an intermediate step of DNA degradation during apoptosis (2000), Genes Dev., 14, 536-548.
    View publication on PubMedView publication on EuropePMC
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Cloned(Commentary)

Cloned (Comment) Organism
gene nuc-1 Caenorhabditis elegans

Protein Variants

Protein Variants Comment Organism
additional information Mutations in nuc-1 block the conversion of TUNEL-reactive DNA to a subsequent TUNEL-unreactive state. Caenorhabditis elegans

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
DNA + H2O Caenorhabditis elegans using TdT-mediated dUTP-nicked-end labelling, TUNEL, is followed DNA fragmentation that occurs in vivo during programmed cell death, Nuc-1 functions in the elimination of TUNEL-reactive DNA ends to a TUNEL nonreactive state 3'-phosphooligonucleotide
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Organism

Organism UniProt Comment Textmining
Caenorhabditis elegans
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Reaction

Reaction Comment Organism Reaction ID
endonucleolytic cleavage to nucleoside 3'-phosphates and 3'-phosphooligonucleotide end-products The pathway for DNA degradation involves three distinct steps. The second step is mediated by the NUC-1. Caenorhabditis elegans
a

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
DNA + H2O degradation of the DNA of apoptotic cells Caenorhabditis elegans 3'-phosphooligonucleotide
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DNA + H2O using TdT-mediated dUTP-nicked-end labelling, TUNEL, is followed DNA fragmentation that occurs in vivo during programmed cell death, Nuc-1 functions in the elimination of TUNEL-reactive DNA ends to a TUNEL nonreactive state Caenorhabditis elegans 3'-phosphooligonucleotide
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Synonyms

Synonyms Comment Organism
Nuc-1 DNase II homolog Caenorhabditis elegans