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Literature summary for 3.1.21.7 extracted from

  • Vik, E.S.; Nawaz, M.S.; Strom Andersen, P.; Fladeby, C.; Bjoras, M.; Dalhus, B.; Alseth, I.
    Endonuclease V cleaves at inosines in RNA (2013), Nat. Commun., 4, 2271.
    View publication on PubMedView publication on EuropePMC

Protein Variants

Protein Variants Comment Organism
D35A inactive Escherichia coli
D52A inactive Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
RNA-DNA hybrid + H2O Escherichia coli the enzyme specifically cleaves the RNA strand of RNA-DNA hybrids. The enzyme is specific for inosine in RNA ?
-
?
RNA-DNA hybrid + H2O Homo sapiens the enzyme specifically cleaves the RNA strand of RNA-DNA hybrids. The enzyme is specific for inosine in RNA. The enzyme cleaves an RNA substrate containing inosine in a position corresponding to a biologically important site for deamination in the Gabra-3 transcript of the GABAA neurotransmitter. Further, the enzyme specifically incises transfer RNAs with inosine in the wobble position ?
-
?

Organism

Organism UniProt Comment Textmining
Escherichia coli
-
-
-
Homo sapiens Q8N8Q3
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
RNA-DNA hybrid + H2O the enzyme specifically cleaves the RNA strand of RNA-DNA hybrids. The enzyme is specific for inosine in RNA Escherichia coli ?
-
?
RNA-DNA hybrid + H2O the enzyme specifically cleaves the RNA strand of RNA-DNA hybrids. The enzyme is specific for inosine in RNA. The enzyme cleaves an RNA substrate containing inosine in a position corresponding to a biologically important site for deamination in the Gabra-3 transcript of the GABAA neurotransmitter. Further, the enzyme specifically incises transfer RNAs with inosine in the wobble position Homo sapiens ?
-
?

Synonyms

Synonyms Comment Organism
endonuclease V
-
Escherichia coli
endonuclease V
-
Homo sapiens
EndoV
-
Escherichia coli
EndoV
-
Homo sapiens