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Literature summary for 3.1.21.4 extracted from

  • Wilkowska, K.; Mruk, I.; Furmanek-Blaszk, B.; Sektas, M.
    Low-level expression of the type II restriction-modification system confers potent bacteriophage resistance in Escherichia coli (2020), DNA Res., 27, dsaa003.
    View publication on PubMed
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Organism

Organism UniProt Comment Textmining
Escherichia coli P00642
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Synonyms

Synonyms Comment Organism
EcoRI
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 Escherichia coli
ecoRIR
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 Escherichia coli

Expression

Organism Comment Expression
Escherichia coli a high expression level of the restriction-modification system results in loss of cell viability. High expression levels of the restriction-modification proteins are associated with reduced restriction of invading bacteriophage DNA additional information

General Information

General Information Comment Organism
metabolism the balance between DNA methylation and cleavage of the type II restriction-modification system may be severely affected by transcriptional signals coming from outside the restriction-modification operon. By modulating the activity of the promoter, a broad range of restriction phenotypes for the EcoRI R-M system can be obtained that differ by up to 4 orders of magnitude in biological assays Escherichia coli