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Literature summary for 3.1.21.3 extracted from
- The Helicobacter pylori HpyAXII restriction-modification system limits exogenous DNA uptake by targeting GTAC sites but shows asymmetric conservation of the DNA methyltransferase and restriction endonuclease components (2008), Nucleic Acids Res., 36, 6893-6906.
Activating Compound
| Activating Compound | Comment | Organism | Structure |
|---|---|---|---|
| additional information | an active R.HpyAXII endonuclease can only exist in the presence of its active DNA MTase partner | Helicobacter pylori |
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
| pCR-TOPO/hpyAXII digested with EcoRI and subcloned into plasmid Bluescript SK+. Plasmid pET15b/hpyAXIIR expressed in Escherichia coli strain BL21CodonPlus(DE3)-RIL | Helicobacter pylori |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| DNA + H2O | Helicobacter pylori | R.HpyAXII effectively restricts chromosomal DNA during natural transformation | ? | - |
? |  |
| DNA + H2O | Helicobacter pylori NSH57 | R.HpyAXII effectively restricts chromosomal DNA during natural transformation | ? | - |
? | |
| plasmid DNA + H2O | Helicobacter pylori | R.HpyAXII effectively restricts unmethylated plasmid during natural transformation | ? | - |
? | |
| plasmid DNA + H2O | Helicobacter pylori NSH57 | R.HpyAXII effectively restricts unmethylated plasmid during natural transformation | ? | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Helicobacter pylori | - |
strains 26695, J99, HPAG1, NSH57and NSH79 | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| DNA + H2O | R.HpyAXII effectively restricts chromosomal DNA during natural transformation | Helicobacter pylori | ? | - |
? | |
| DNA + H2O | R.HpyAXII effectively restricts chromosomal DNA during natural transformation | Helicobacter pylori NSH57 | ? | - |
? | |
| plasmid DNA + H2O | R.HpyAXII effectively restricts unmethylated plasmid during natural transformation | Helicobacter pylori | ? | - |
? | |
| plasmid DNA + H2O | R.HpyAXII effectively restricts unmethylated plasmid during natural transformation | Helicobacter pylori NSH57 | ? | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| HpyAXII restriction-modification system | - |
Helicobacter pylori |
| R.HpyAXII | - |
Helicobacter pylori |
| type II R-M system | - |
Helicobacter pylori |
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