Literature summary for 3.1.21.2 extracted from

Ivanov, I.; Tainer, J.A.; McCammon, J.A.
Unraveling the three-metal-ion catalytic mechanism of the DNA repair enzyme endonuclease IV (2007), Proc. Natl. Acad. Sci. USA, 104, 1465-1470.

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Organism

Organism	UniProt	Comment	Textmining
Escherichia coli	P0A6C1	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
additional information	reaction proceeds through a synchronous bimolecular (ANDN) mechanism with reaction free energy and barrier of -3.5 and 20.6 kcal/mol.In the course of the reaction the trinuclear active site of endonuclease IV undergoes dramatic local conformational changes: shifts in the mode of coordination of both substrate and first-shell ligands	Escherichia coli	?	-	?

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Release 2023.1 (January 2023)