Literature summary for 3.1.21.1 extracted from

Das, T.; Simone, M.; Ibugo, A.I.; Witting, P.K.; Manefield, M.; Manos, J.
Glutathione enhances antibiotic efficiency and effectiveness of DNase I in disrupting Pseudomonas aeruginosa biofilms while also inhibiting pyocyanin activity, thus facilitating restoration of cell enzymatic activity, confluence and viability (2017), Front. Microbiol., 8, 2429 .

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Application

Application	Comment	Organism
pharmacology	bacterial biofilm infections are highly prevalent and are a significant cause of morbidity and mortality. With the rapid emergence of resistance to conventional antibiotic therapies and intrinsic biofilm resistance to antibiotic penetration, Pseudomonas aeruginosa biofilm treatment options are limited. Consequently, novel anti-biofilm strategies to prevent biofilm formation and remove existing biofilms are being sought. Glutathione enhances antibiotic efficiency and effectiveness of DNase I in disrupting Pseudomonas aeruginosa biofilms while also inhibiting pyocyanin activity, Thus facilitating restoration of cell enzymatic activity, confluence and viability	Bos taurus

Organism

Organism	UniProt	Comment	Textmining
Bos taurus	P00639	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
pancreas	-	Bos taurus	-

Synonyms

Synonyms	Comment	Organism
DNase I	-	Bos taurus

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Release 2023.1 (January 2023)