Literature summary for 3.1.21.1 extracted from

Tsutsumi, S.; Kaneko, Y.; Asao, T.; Kuwano, H.; Kudo, S.; Takeshita, H.; Yasuda, T.; Kishi, K.
DNase I is present in the chief cells of human and rat stomachs (2002), Histochem. J., 33, 531-535.

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Localization

Localization	Comment	Organism	GeneOntology No.	Textmining
cytoplasm	-	Homo sapiens	5737	-
cytoplasm	-	Rattus norvegicus	5737	-
extracellular	-	Homo sapiens	-	-
extracellular	-	Rattus norvegicus	-	-
secretory granule	exocrine	Homo sapiens	30141	-
secretory granule	exocrine	Rattus norvegicus	30141	-

Metals/Ions

Metals/Ions	Comment	Organism	Structure
Ca2+	-	Homo sapiens
Ca2+	-	Rattus norvegicus
Mg2+	-	Homo sapiens
Mg2+	-	Rattus norvegicus

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-
Rattus norvegicus	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
chief cell	enzyme secretion	Homo sapiens	-
chief cell	enzyme secretion	Rattus norvegicus	-
gastric fundus	-	Homo sapiens	-
gland	pars glandularis	Rattus norvegicus	-
additional information	secretion of enzyme is controlled by the chief cells in the stomach	Homo sapiens	-
additional information	secretion of enzyme is controlled by the chief cells in the stomach	Rattus norvegicus	-
stomach	-	Homo sapiens	-
stomach	-	Rattus norvegicus	-
tela submucosa	-	Homo sapiens	-
tela submucosa	-	Rattus norvegicus	-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg]	Specific Activity Maximum [µmol/min/mg]	Comment	Organism
additional information	-	RT-PCR-based and immunohistochemic detection and quantification	Homo sapiens
additional information	-	RT-PCR-based immunohistochemic detection and quantification	Rattus norvegicus

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
dsDNA + H2O	predominant single-strand nicking in presence of Mg2+ and Ca2+	Homo sapiens	5'-phosphodinucleotide + 5'-phosphooligonucleotide	-	?
dsDNA + H2O	predominant single-strand nicking in presence of Mg2+ and Ca2+	Rattus norvegicus	5'-phosphodinucleotide + 5'-phosphooligonucleotide	-	?

Synonyms

Synonyms	Comment	Organism
DNase I	-	Homo sapiens
DNase I	-	Rattus norvegicus

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Release 2023.1 (January 2023)