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Literature summary for 3.1.2.6 extracted from

  • Cordell, P.A.; Futers, T.S.; Grant, P.J.; Pease, R.J.
    The human hydroxyacylglutathione hydrolase (HAGH) gene encodes both cytosolic and mitochondrial forms of glyoxalase II (2004), J. Biol. Chem., 279, 28653-28661.
    View publication on PubMed

Cloned(Commentary)

Cloned (Comment) Organism
DNA sequence determination and analysis of the single HAGH gene encoding both the cytosolic and mitochondrial isozymes, in vitro transcription, 2 splicing forms of mRNA Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
cytosol
-
Homo sapiens 5829
-
cytosol cytosolic isozyme Homo sapiens 5829
-
mitochondrial matrix mitochondrial isozyme is targeted directly to the mitochondrial matrix due to a mitochondrial targeting sequence Homo sapiens 5759
-
mitochondrion
-
Homo sapiens 5739
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
S-D-lactoylglutathione + H2O Homo sapiens
-
glutathione + D-lactate
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
HAGH gene encodes both cytosolic and mitochondrial forms of glyoxalase II
-
Homo sapiens Q16775 cytosolic and mitochondrial isozyme, both encoded by gene HAGH for hydroxyacylglutathione hydrolase
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information enzyme shows broad substrate specificity with a preference for 2-hydoxy thiol esters Homo sapiens ?
-
?
S-D-lactoylglutathione + H2O
-
Homo sapiens glutathione + D-lactate
-
?

Synonyms

Synonyms Comment Organism
acetoacetylglutathione hydrolase
-
Homo sapiens
Germ cell specific protein
-
Homo sapiens
GLO II
-
Homo sapiens
glyoxalase II
-
Homo sapiens
HAGH
-
Homo sapiens
hydrolase, acetoacetylglutathione
-
Homo sapiens
hydrolase, hydroxyacylglutathione
-
Homo sapiens
More enzyme is a member of the zinc metallohydrolase family with a beta-lactamase fold Homo sapiens
Round spermatid protein RSP29
-
Homo sapiens
S-2-hydroxylacylglutathione hydrolase
-
Homo sapiens