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Literature summary for 3.1.2.6 extracted from
- In situ kinetic analysis of glyoxalase I and glyoxalase II in Saccharomyces cerevisiae (2001), Eur. J. Biochem., 268, 3930-3936.
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| additional information | - |
additional information | kinetics of the enzyme in situ, cells being permeabilized by digitonin | Saccharomyces cerevisiae | |
| 0.32 | - |
S-D-lactoylgutathione | pH 6.5, 30°C, substrate concentration 1.5-3 mM | Saccharomyces cerevisiae |  |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| S-D-lactoylglutathione + H2O | Saccharomyces cerevisiae | enzyme is involved in the detoxification of methylglyoxal | glutathione + D-lactate | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Saccharomyces cerevisiae | - |
- |
- |
Reaction
| Reaction | Comment | Organism | Reaction ID |
|---|---|---|---|
| S-(2-hydroxyacyl)glutathione + H2O = glutathione + a 2-hydroxy carboxylate | reaction mechanism | Saccharomyces cerevisiae |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| S-D-lactoylglutathione + H2O | - |
Saccharomyces cerevisiae | glutathione + D-lactate | - |
? | |
| S-D-lactoylglutathione + H2O | enzyme is involved in the detoxification of methylglyoxal | Saccharomyces cerevisiae | glutathione + D-lactate | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| acetoacetylglutathione hydrolase | - |
Saccharomyces cerevisiae |
| Germ cell specific protein | - |
Saccharomyces cerevisiae |
| GLO II | - |
Saccharomyces cerevisiae |
| glyoxalase II | - |
Saccharomyces cerevisiae |
| hydrolase, acetoacetylglutathione | - |
Saccharomyces cerevisiae |
| hydrolase, hydroxyacylglutathione | - |
Saccharomyces cerevisiae |
| Round spermatid protein RSP29 | - |
Saccharomyces cerevisiae |
| S-2-hydroxylacylglutathione hydrolase | - |
Saccharomyces cerevisiae |
Temperature Optimum [°C]
| Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
|---|---|---|---|
| 30 | - |
assay at | Saccharomyces cerevisiae |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 6.5 | - |
assay at | Saccharomyces cerevisiae |
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Release 2023.1 (January 2023)
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