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Literature summary for 3.1.2.4 extracted from

  • Shimomura, Y.; Murakami, T.; Fujitsuka, N.; Nakai, N.; Sato, Y.; Sugiyama, S.; Shimomura, N.; Irwin, J.; Hawes, J.W.; Harris, R.A.
    Purification and partial characterization of 3-hydroxyisobutyryl-coenzyme A hydrolase of rat liver (1994), J. Biol. Chem., 269, 14248-14253.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
acetoacetyl-CoA competitive Rattus norvegicus
acetyl-CoA competitive Rattus norvegicus
DL-3-hydroxybutyryl-CoA competitive Rattus norvegicus
DL-methylmalonyl-CoA competitive Rattus norvegicus
isobutyryl-CoA competitive Rattus norvegicus
malonyl-CoA competitive Rattus norvegicus
n-valeryl-CoA competitive Rattus norvegicus
propionyl-CoA competitive Rattus norvegicus

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.006
-
3-hydroxy-2-methylpropanoyl-CoA
-
Rattus norvegicus
0.025
-
3-hydroxypropionyl-CoA
-
Rattus norvegicus

Localization

Localization Comment Organism GeneOntology No. Textmining
mitochondrion
-
Rattus norvegicus 5739
-

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
36000
-
gel filtration Rattus norvegicus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3-hydroxy-2-methylpropanoyl-CoA + H2O Rattus norvegicus enzyme is involved in Val catabolism. The enzyme protects cells against toxic effects of methacrylyl-CoA, an intermediate in the Val pathway occuring upstream of 3-hydroxy-2-methylpropanoyl-CoA ?
-
?

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
-
-
-

Purification (Commentary)

Purification (Comment) Organism
-
Rattus norvegicus

Source Tissue

Source Tissue Comment Organism Textmining
brain
-
Rattus norvegicus
-
heart
-
Rattus norvegicus
-
kidney
-
Rattus norvegicus
-
liver
-
Rattus norvegicus
-
muscle
-
Rattus norvegicus
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
427
-
-
Rattus norvegicus

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
(S)-methylmalonyl-CoA + H2O
-
Rattus norvegicus CoA + methylmalonate
-
?
3-hydroxy-2-methylpropanoyl-CoA + H2O
-
Rattus norvegicus CoA + 3-hydroxy-2-methylpropanoate
-
?
3-hydroxy-2-methylpropanoyl-CoA + H2O enzyme is involved in Val catabolism. The enzyme protects cells against toxic effects of methacrylyl-CoA, an intermediate in the Val pathway occuring upstream of 3-hydroxy-2-methylpropanoyl-CoA Rattus norvegicus ?
-
?
3-hydroxypropanoyl-CoA + H2O
-
Rattus norvegicus CoA + 3-hydroxypropanoate
-
?

Subunits

Subunits Comment Organism
monomer 1 * 36000, SDS-PAGE Rattus norvegicus

Turnover Number [1/s]

Turnover Number Minimum [1/s] Turnover Number Maximum [1/s] Substrate Comment Organism Structure
150
-
3-hydroxy-2-methylpropanoyl-CoA
-
Rattus norvegicus
266
-
3-hydroxy-2-methylpropanoyl-CoA
-
Rattus norvegicus

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
6
-
hydrolysis of (S)-methylmalonyl-CoA Rattus norvegicus
8
-
hydrolysis of 3-hydroxy-2-methylpropanoyl-CoA Rattus norvegicus

pH Range

pH Minimum pH Maximum Comment Organism
5 7 pH 5.0, about 30% of maximal activity, pH 7.0: 65% of maximal activity, hydrolysis of (S)-methylmalonyl-CoA Rattus norvegicus
5 10.5 pH 5.0: about 40% of maximal activity, pH 10.5: about 80% of maximal activity, hydrolysis of 3-hydroxy-2-methylpropanoyl-CoA Rattus norvegicus