Literature summary for 3.1.2.32 extracted from

Zender, M.; Witzgall, F.; Drees, S.L.; Weidel, E.; Maurer, C.K.; Fetzner, S.; Blankenfeldt, W.; Empting, M.; Hartmann, R.W.
Dissecting the multiple roles of PqsE in Pseudomonas aeruginosa virulence by discovery of small tool compounds (2016), ACS Chem. Biol., 11, 1755-1763.

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Cloned(Commentary)

Cloned (Comment)	Organism
-	Pseudomonas aeruginosa

Crystallization (Commentary)

Crystallization (Comment)	Organism
in complex with inhibitors 2-aminobenzoylacetate, 2-(pyridin-3-yl)benzoic acid, 2-(1H-pyrrol-1-yl)benzoic acid and 3-methylthiophene-2-carboxylic acid	Pseudomonas aeruginosa

Inhibitors

Inhibitors	Comment	Organism	Structure
2-(1H-pyrrol-1-yl)benzoic acid	compound binds to the active center, presence does not affect the levels of the PqsE-regulated virulence factor pyocyanin	Pseudomonas aeruginosa
2-(pyridin-3-yl)benzoic acid	compound binds to the active center, presence does not affect the levels of the PqsE-regulated virulence factor pyocyanin	Pseudomonas aeruginosa
2-aminobenzoylacetate	compound binds to the active center, presence does not affect the levels of the PqsE-regulated virulence factor pyocyanin	Pseudomonas aeruginosa
3-methylthiophene-2-carboxylic acid	compound binds to the active center, presence does not affect the levels of the PqsE-regulated virulence factor pyocyanin	Pseudomonas aeruginosa

Organism

Organism	UniProt	Comment	Textmining
Pseudomonas aeruginosa	P20581	-	-
Pseudomonas aeruginosa DSM 22644	P20581	-	-

Synonyms

Synonyms	Comment	Organism
pqsE	-	Pseudomonas aeruginosa

IC50 Value

IC50 Value	IC50 Value Maximum	Comment	Organism	Inhibitor	Structure
0.025	-	pH 8.5, 21°C	Pseudomonas aeruginosa	2-(pyridin-3-yl)benzoic acid
0.04	-	pH 8.5, 21°C	Pseudomonas aeruginosa	3-methylthiophene-2-carboxylic acid
0.155	-	pH 8.5, 21°C	Pseudomonas aeruginosa	2-(1H-pyrrol-1-yl)benzoic acid

General Information

General Information	Comment	Organism
physiological function	enzyme is part of the quinolone signal pathway. The regulatory function of PqsE is not linked to its thioesterase activity and must be encoded outside of the active center	Pseudomonas aeruginosa

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Release 2023.1 (January 2023)