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Literature summary for 3.1.2.20 extracted from
- Studies on the mechanism of fatty acid synthesis. XIX. Preparation and general properties of palmityl thioesterase (1968), J. Biol. Chem., 243, 2955-2962.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| diisopropylfluorophosphate | at 0.01 mM inhibition of 95% after 40 min. | Escherichia coli |  |
Molecular Weight [Da]
| Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|
| 20000 | - |
sedimentation velocity | Escherichia coli |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| palmitoyl-CoA + H2O | Escherichia coli | - |
CoA + palmitate | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Columba sp. | - |
- |
- |
| Escherichia coli | - |
- |
- |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
| 260fold | Escherichia coli |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| liver | - |
Columba sp. | - |
Specific Activity [micromol/min/mg]
| Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
|---|---|---|---|
| 3.7 | - |
- |
Escherichia coli |
Storage Stability
| Storage Stability | Organism |
|---|---|
| -20°C over 1 month | Escherichia coli |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| dodecanoyl-CoA + H2O | i.e. lauroyl-CoA | Escherichia coli | CoA + dodecanoate | - |
? | |
| hexadecanoyl-CoA + H2O | i.e. palmitoyl-CoA | Escherichia coli | CoA + hexadecanoate | - |
ir | |
| octadecanoyl-CoA + H2O | i.e. stearoyl-CoA | Escherichia coli | CoA + octadecanoate | - |
? | |
| oleoyl-CoA + H2O | - |
Escherichia coli | CoA + oleate | - |
? | |
| palmitoleoyl-CoA + H2O | - |
Escherichia coli | CoA + palmitoleoate | - |
? | |
| palmitoyl-CoA + H2O | - |
Escherichia coli | CoA + palmitate | - |
? | |
| tetradecanoyl-CoA + H2O | i.e. myristoyl-CoA | Escherichia coli | CoA + tetradecanoate | - |
? | |
| vaccenoyl-CoA + H2O | cis-isomer | Escherichia coli | CoA + vaccenoate | - |
? | |
Subunits
| Subunits | Comment | Organism |
|---|---|---|
| dimer | - |
Escherichia coli |
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Release 2023.1 (January 2023)
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