Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 3.1.2.2 extracted from

  • Forwood, J.K.; Thakur, A.S.; Guncar, G.; Marfori, M.; Mouradov, D.; Meng, W.; Robinson, J.; Huber, T.; Kellie, S.; Martin, J.L.; Hume, D.A.; Kobe, B.
    Structural basis for recruitment of tandem hotdog domains in acyl-CoA thioesterase 7 and its role in inflammation (2007), Proc. Natl. Acad. Sci. USA, 104, 10382-10387.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.1.2.2

Cloned(Commentary)

Cloned (Comment) Organism
-
 Mus musculus

Crystallization (Commentary)

Crystallization (Comment) Organism
hanging-drop vapor diffusion in 20% PEG 2000. Crystal structures of both the N- and C-terminal domains of the mouse enzyme. The quaternary arrangement in Acot7 features a trimer of hotdog fold dimers Mus musculus

Protein Variants

Protein Variants Comment Organism
D213A mutation results in a strong reduction in catalytic activity Mus musculus
E39A mutation does not affect activity Mus musculus
E39D/T198N mutant displays a 4fold increase in the catalytic activity compared with wild-type Acot7 Mus musculus
N24A mutation results in a strong reduction in catalytic activity Mus musculus
T198A mutation does not affect activity Mus musculus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Mus musculus role in eicosanoid synthesis and inflammation ?
-
 ?

Organism

Organism UniProt Comment Textmining
Mus musculus Q91V12
-
-

Purification (Commentary)

Purification (Comment) Organism
-
 Mus musculus

Source Tissue

Source Tissue Comment Organism Textmining
macrophage up-regulated by lipopolysaccharide and that overexpression of Acot7 in a macrophage cell line alters the production of prostaglandins D2 and E2 Mus musculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
arachidonoyl-CoA + H2O
-
 Mus musculus CoA + arachidonate
-
 ?
lauroyl-CoA + H2O
-
 Mus musculus CoA + laurate
-
 ?
additional information role in eicosanoid synthesis and inflammation Mus musculus ?
-
 ?
octanoyl-CoA + H2O
-
 Mus musculus CoA + octanoate
-
 ?
palmitoyl-CoA + H2O
-
 Mus musculus CoA + palmitate
-
 ?

Synonyms

Synonyms Comment Organism
Acot7
-
 Mus musculus
acyl-CoA thioesterase 7
-
 Mus musculus