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Literature summary for 3.1.2.2 extracted from

  • King, K.L.; Young, M.E.; Kerner, J.; Huang, H.; OShea, K.M.; Alexson, S.E.; Hoppel, C.L.; Stanley, W.C.
    Diabetes or peroxisome proliferator-activated receptor alpha agonist increases mitochondrial thioesterase I activity in heart (2007), J. Lipid Res., 48, 1511-1517.
    View publication on PubMed
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Localization

Localization Comment Organism GeneOntology No. Textmining
mitochondrion
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 Rattus norvegicus 5739
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Organism

Organism UniProt Comment Textmining
Rattus norvegicus Q6IMX8 male Wistar
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Source Tissue

Source Tissue Comment Organism Textmining
heart treatment with a PPARalpha agonist (peroxisome proliferator-activated receptor alpha agonist) increases MTE-1 mRNA, protein expression, and activity and the rate of palmitate export from isolated cardiac mitochondria, suggesting that MTE-I functions to regulate the concentration of long-chain fatty acyl-CoA in the mitochondrial matrix through the generation and export of free fatty acid anions. Thus, upregulation of MTE-I activity may prevent the accumulation of long-chain fatty acyl-CoA in the mitochondrial matrix when the heart is exposed to high levels of fatty acids Rattus norvegicus
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
palmitoyl-CoA + H2O
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 Rattus norvegicus CoA + palmitate
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 ?

Synonyms

Synonyms Comment Organism
mitochondrial thioesterase I
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 Rattus norvegicus
MTE-I
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 Rattus norvegicus