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Literature summary for 3.1.2.2 extracted from

  • Hunt, M.C.; Solaas, K.; Kase, B.F.; Alexson, S.E.
    Characterization of an acyl-coA thioesterase that functions as a major regulator of peroxisomal lipid metabolism (2002), J. Biol. Chem., 277, 1128-1138.
    View publication on PubMed

Activating Compound

Activating Compound Comment Organism Structure
additional information fasting induces enzyme expression, dependent on peroxisome proliferator-activated receptor alpha Mus musculus
peroxisome proliferator WY-14,643 induction of enzyme expression, dependent on peroxisome proliferator-activated receptor alpha Mus musculus
PPARalpha internal receptor protein essential for effect of stimulating compounds Mus musculus
PPARalpha i.e. peroxisome proliferator-activated receptor alpha Mus musculus

Cloned(Commentary)

Cloned (Comment) Organism
DNA sequence determination and analysis, expression in Escherichia coli BL21(DE3) Mus musculus
isozyme PTE-2, DNA sequence determination and analysis Homo sapiens
isozyme PTE-2, DNA sequence determination and analysis, expression as green-fluorescent-protein fusion protein in human skin fibroblasts Mus musculus

Inhibitors

Inhibitors Comment Organism Structure
acyl-CoA substrate inhibition at concentrations higher than 0.005-0.01 mM of acyl-CoA longer than C10, BSA protects Mus musculus
CoA intraperoxisomal regulatory role Mus musculus

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
additional information
-
additional information
-
Mus musculus
additional information
-
additional information diverse substrates, kinetics Mus musculus
0.0014
-
palmitoleoyl-CoA pH 7.4 Mus musculus
0.0017
-
hexadecanoyl-CoA pH 7.4 Mus musculus
0.0023
-
linoleoyl-CoA pH 7.4 Mus musculus
0.0025
-
tetradecanoyl-CoA pH 7.4 Mus musculus
0.0042
-
arachidoyl-CoA pH 7.4 Mus musculus
0.0063
-
trihydroxycoprostanoyl-CoA pH 7.4 Mus musculus
0.0067
-
Arachidonoyl-CoA pH 7.4 Mus musculus
0.0088
-
chenodeoxycholoyl-CoA pH 7.4 Mus musculus
0.0146
-
choloyl-CoA pH 7.4 Mus musculus

Localization

Localization Comment Organism GeneOntology No. Textmining
peroxisome isozyme PTE-II Mus musculus 5777
-
peroxisome isozyme PTE-2, major acyl-CoA thioesterase in peroxisomes Homo sapiens 5777
-
peroxisome isozyme PTE-2, major acyl-CoA thioesterase in peroxisomes Mus musculus 5777
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
4,8-dimethylnonanoyl-CoA + H2O Mus musculus
-
CoA + 4,8-dimethylnonanoate
-
?
additional information Homo sapiens enzyme might play an important role in prevention of CoA sequestration and in facilitating excretion of chain-shortened carboxylic acids, enzyme has a key regulatory function in peroxisomal lipid metabolism ?
-
?
additional information Mus musculus enzyme might play an important role in prevention of CoA sequestration and in facilitating excretion of chain-shortened carboxylic acids, enzyme has a key regulatory function in peroxisomal lipid metabolism ?
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens O14734
-
-
Mus musculus P58137 gene pte-2, isozyme PTE-II
-
Mus musculus P58137 adult male C57 BL/6 mice, peroxisomal isozyme PTE-2
-

Purification (Commentary)

Purification (Comment) Organism
recombinant from Escherichia coli Mus musculus

Reaction

Reaction Comment Organism Reaction ID
palmitoyl-CoA + H2O = CoA + palmitate catalytic triad D233-S255-Q305 Mus musculus

Source Tissue

Source Tissue Comment Organism Textmining
heart
-
Mus musculus
-
kidney
-
Mus musculus
-
liver
-
Mus musculus
-
additional information ubiquitous expression Mus musculus
-
muscle
-
Mus musculus
-
testis
-
Mus musculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2-methylstearoyl-CoA + H2O
-
Mus musculus CoA + 2-methylstearate
-
?
2-trans-decenoyl-CoA + H2O
-
Mus musculus CoA + 2-trans-decenoate
-
?
3-hydroxy-3-methyl glutaryl-CoA + H2O
-
Mus musculus CoA + 3-hydroxy-3-methyl glutarate
-
?
3-hydroxy-3-methylglutaryl-CoA + H2O
-
Mus musculus CoA + 3-hydroxy-3-methylglutarate
-
?
3-hydroxyhexadecanoyl-CoA + H2O
-
Mus musculus CoA + 3-hydroxyhexadecanoate
-
?
3-hydroxypalmitoyl-CoA + H2O
-
Mus musculus CoA + 3-hydroxypalmitate
-
?
4,8-dimethylnonanoyl-CoA + H2O
-
Mus musculus CoA + 4,8-dimethylnonanoate
-
?
acetoacetyl-CoA + H2O
-
Mus musculus CoA + acetoacetate
-
?
acetyl-CoA + H2O
-
Mus musculus CoA + acetate
-
?
acyl-CoA + H2O long-chain fatty-acyl-CoA Mus musculus CoA + a carboxylate
-
?
arachidonoyl-CoA + H2O
-
Mus musculus CoA + arachidonate
-
?
arachidoyl-CoA + H2O
-
Mus musculus CoA + arachidate
-
?
butyryl-CoA + H2O
-
Mus musculus butanoate + CoA
-
?
chenodeoxycholoyl-CoA + H2O activity is PPARalpha-inducible Mus musculus CoA + chenodeoxycholoate
-
?
chenodeoxycholoyl-CoA + H2O bile acid derivative substrate Mus musculus CoA + chenodeoxycholoate
-
?
chenodeoxycholoyl-CoA + H2O
-
Mus musculus CoA + chenodeoxycholate
-
?
choloyl-CoA + H2O activity is PPARalpha-inducible Mus musculus CoA + choloate
-
?
choloyl-CoA + H2O bile acid derivative substrate Mus musculus CoA + choloate
-
?
choloyl-CoA + H2O best substrate Mus musculus CoA + cholate
-
?
clofibroyl-CoA + H2O
-
Mus musculus CoA + clofibrate
-
?
decanoyl-CoA + H2O
-
Mus musculus CoA + decanoate
-
?
dodecanoyl-CoA + H2O
-
Mus musculus CoA + dodecanoate
-
?
hexadecanoyl-CoA + H2O
-
Mus musculus CoA + hexadecanoate
-
?
hexanoyl-CoA + H2O
-
Mus musculus CoA + hexanoate
-
?
hexanoyl-CoA + H2O
-
Mus musculus CoA + n-hexanoate
-
?
lauroyl-CoA + H2O
-
Mus musculus CoA + laurate
-
?
linoleoyl-CoA + H2O
-
Mus musculus CoA + linoleate
-
?
malonyl-CoA + H2O
-
Mus musculus CoA + malonate
-
?
additional information broad chain length specificity Mus musculus ?
-
?
additional information enzyme might play an important role in prevention of CoA sequestration and in facilitating excretion of chain-shortened carboxylic acids, enzyme has a key regulatory function in peroxisomal lipid metabolism Homo sapiens ?
-
?
additional information enzyme might play an important role in prevention of CoA sequestration and in facilitating excretion of chain-shortened carboxylic acids, enzyme has a key regulatory function in peroxisomal lipid metabolism Mus musculus ?
-
?
myristoleoyl-CoA + H2O
-
Mus musculus myristoleoate + CoA
-
?
myristoyl-CoA + H2O
-
Mus musculus CoA + myristate
-
?
n-butyryl-CoA + H2O
-
Mus musculus CoA + n-butanoate
-
?
octadecanoyl-CoA + H2O
-
Mus musculus CoA + octadecanoate
-
?
octanoyl-CoA + H2O
-
Mus musculus CoA + octanoate
-
?
oleoyl-CoA + H2O
-
Mus musculus CoA + oleate
-
?
palmitoleoyl-CoA + H2O
-
Mus musculus CoA + palmitoleoate
-
?
palmitoyl-CoA + H2O
-
Homo sapiens CoA + palmitate
-
?
palmitoyl-CoA + H2O
-
Mus musculus CoA + palmitate
-
?
propionyl-CoA + H2O
-
Mus musculus CoA + propionate
-
?
prostaglandin F2alpha + H2O
-
Mus musculus ?
-
?
prostaglandin F2alpha-CoA + H2O
-
Mus musculus prostaglandin F2alpha + CoA
-
?
stearoyl-CoA + H2O
-
Mus musculus CoA + stearate
-
?
tetradecanoyl-CoA + H2O
-
Mus musculus CoA + tetradecanoate
-
?
trihydroxycoprostanoyl-CoA + H2O
-
Mus musculus CoA + trihydroxycoprostanoate
-
?

Synonyms

Synonyms Comment Organism
peroxisomal acyl-CoA thioesterase 2
-
Homo sapiens
peroxisomal acyl-CoA thioesterase 2
-
Mus musculus
PTE-2
-
Homo sapiens
PTE-2
-
Mus musculus

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.4
-
assay at Mus musculus