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Literature summary for 3.1.13.4 extracted from

  • Godwin, A.; Kojima, S.; Green, C.; Wilusz, J.
    Kiss your tail goodbye The role of PARN, Nocturnin, and Angel deadenylases in mRNA biology (2013), Biochim. Biophys. Acta, 1829, 571-579 .
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.1.13.4

Organism

Organism UniProt Comment Textmining
Homo sapiens O95453
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Mus musculus O35710
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Mus musculus Q8VDG3
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-

Synonyms

Synonyms Comment Organism
PARN
-
 Homo sapiens
PARN
-
 Mus musculus

Expression

Organism Comment Expression
Mus musculus nocturin deadenylase shows rhythmic expression under circadian control. It is rapidly induced in response to serum shock, LPS and other stimuli up

General Information

General Information Comment Organism
malfunction Noc knock-out (Noc-/-) mice exhibit no obvious abnormalities in development or reproduction, however, they exhibit striking metabolic phenotypes when fed a High-Fat Diet (HFD). This diet causes wild-type mice to become obese, but the Noc-/- mice remain lean although they do not exhibit increased activity or reduced food intake Mus musculus
physiological function PARN, nocturnin and Angel are three of the multiple deadenylases that have been described in eukaryotic cells. While each of these enzymes appears to target poly(A) tails for shortening and influence RNA gene expression levels and quality control, the enzymes differ in terms of enzymatic mechanisms, regulation and biological impact. Nocturnin functions in adipogenesis and lipid metabolism Mus musculus
physiological function PARN, nocturnin and Angel are three of the multiple deadenylases that have been described in eukaryotic cells. While each of these enzymes appears to target poly(A) tails for shortening and influence RNA gene expression levels and quality control, the enzymes differ in terms of enzymatic mechanisms, regulation and biological impact. PARN plays a role in early development, DNA damage and possibly cancer Homo sapiens
physiological function PARN, nocturnin and Angel are three of the multiple deadenylases that have been described in eukaryotic cells. While each of these enzymes appears to target poly(A) tails for shortening and influence RNA gene expression levels and quality control, the enzymes differ in terms of enzymatic mechanisms, regulation and biological impact. PARN plays a role in early development, DNA damage and possibly cancer Mus musculus