Literature summary for 3.1.13.4 extracted from

Ishikawa, H.; Yoshikawa, H.; Izumikawa, K.; Miura, Y.; Taoka, M.; Nobe, Y.; Yamauchi, Y.; Nakayama, H.; Simpson, R.J.; Isobe, T.; Takahashi, N.
Poly(A)-specific ribonuclease regulates the processing of small-subunit rRNAs in human cells (2017), Nucleic Acids Res., 45, 3437-3447 .

Search for more literature for 3.1.13.4

Protein Variants

Protein Variants	Comment	Organism
D28A	site-directed mutagenesis, catalytically inactive mutant, phenotype, overview	Homo sapiens

Localization

Localization	Comment	Organism	GeneOntology No.	Textmining
additional information	PARN, as a component of the pre-40S particle, pulls down with the pre-ribosome factor LTV1 or Bystin. PARN is a constitutive component of the Bystin-associated pre-40S particle	Homo sapiens	-	-

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
18S-E pre-rRNA + H2O	Homo sapiens	-	?	-	?

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	O95453	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
18S-E pre-rRNA + H2O	-	Homo sapiens	?	-	?

Synonyms

Synonyms	Comment	Organism
PARN	-	Homo sapiens

General Information

General Information	Comment	Organism
malfunction	knockdown of PARN or exogenous expression of an enzyme-dead PARN mutant (D28A) accumulates 18S-E in both the cytoplasm and nucleus. Expression of D28A accumulates 18S-E in Bystin-associated pre-40S particles. RNase H-based fragmentation analysis and 3'-sequence analysis of 18S-E species present in cells expressing wild-type PARN or D28A, overview	Homo sapiens
physiological function	poly(A)-specific ribonuclease regulates the processing of small-subunit rRNAs in human cells, poly(A)-specific ribonuclease (PARN) participates in steps leading to 18S-E maturation in human cells. Ribosome biogenesis occurs successively in the nucleolus, nucleoplasm, and cytoplasm. Maturation of the ribosomal small subunit is completed in the cytoplasm by incorporation of a particular class of ribosomal proteins and final cleavage of 18S-E pre-rRNA (18S-E). The enzymatic activity of PARN is necessary for the release of 18S-E from Bystin-associated pre-40S particles. PARN degrades the extended regions encompassing nucleotides 5-44 at the 3' end of mature 18S rRNA	Homo sapiens

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Release 2023.1 (January 2023)