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BRENDA support

Literature summary for 3.1.13.3 extracted from

  • Bruni, F.; Gramegna, P.; Oliveira, J.M.; Lightowlers, R.N.; Chrzanowska-Lightowlers, Z.M.
    REXO2 is an oligoribonuclease active in human mitochondria (2013), PLoS ONE, 8, e64670.
    View publication on PubMedView publication on EuropePMC

Localization

Localization Comment Organism GeneOntology No. Textmining
cytosol dual cellular localization being present both in cytosolic and mitochondrial fractions Homo sapiens 5829
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mitochondrion dual cellular localization being present both in cytosolic and mitochondrial fractions. The mitochondrial form localizes to both the intermembrane space and the matrix Homo sapiens 5739
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Organism

Organism UniProt Comment Textmining
Homo sapiens Q9Y3B8
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-

Synonyms

Synonyms Comment Organism
REXO2
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Homo sapiens

General Information

General Information Comment Organism
physiological function depletion of isoform REXO2 by RNA interference causes a strong morphological phenotype in human cells, which show a disorganized network of punctate and granular mitochondria. Lack of REXO2 protein also causes a substantial decrease of mitochondrial nucleic acid content and impaires de novo mitochondrial protein synthesis Homo sapiens