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Literature summary for 3.1.13.3 extracted from

  • Futai, M.; Mizuno, D.
    A new phosphodiesterase forming nucleoside 5'-monophosphate from rat liver. Its partial purification and substrate specificity for nicotinamide adenine dinucleotide and oligonucleotides (1967), J. Biol. Chem., 242, 5301-5307.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
3'-AMP slight Rattus norvegicus
5'-AMP
-
Rattus norvegicus
5'-UMP
-
Rattus norvegicus
ADP
-
Rattus norvegicus
ATP
-
Rattus norvegicus
beta-mercaptoethanol slight Rattus norvegicus
CuCl2 slight Rattus norvegicus
EDTA
-
Rattus norvegicus
HgCl2
-
Rattus norvegicus
p-chloromercuribenzoate slight Rattus norvegicus
UDP
-
Rattus norvegicus

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.41
-
p-nitrophenyl uridine 5'-monophosphate
-
Rattus norvegicus

Metals/Ions

Metals/Ions Comment Organism Structure
Ca2+ activation Rattus norvegicus
Co2+ activation Rattus norvegicus
K+ activates at high concentration Rattus norvegicus
Mg2+ activation Rattus norvegicus
Na+ activates at high concentration Rattus norvegicus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
oligonucleotides + H2O Rattus norvegicus
-
nucleoside 5'-phosphates
-
?

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
-
-
-

Purification (Commentary)

Purification (Comment) Organism
-
Rattus norvegicus

Source Tissue

Source Tissue Comment Organism Textmining
liver
-
Rattus norvegicus
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
1.2
-
p-nitrophenyl uridine 5'-monophosphate Rattus norvegicus

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
DNA + H2O hydrolyzed very slowly, not: ADP, UDP, ATP, UTP Rattus norvegicus nucleoside 5'-phosphates
-
?
NAD+ + H2O
-
Rattus norvegicus NMN + AMP
-
?
oligonucleotides + H2O
-
Rattus norvegicus nucleoside 5'-phosphates
-
?
oligonucleotides + H2O no base specificity Rattus norvegicus nucleoside 5'-phosphates
-
?
oligonucleotides + H2O initial site of attack: 3'-hydroxyl end Rattus norvegicus nucleoside 5'-phosphates
-
?
p-nitrophenyl uridine 5'-monophosphate + H2O
-
Rattus norvegicus p-nitrophenol + 5'-UMP
-
?
p-nitrophenyl-2',3'-isopropyl-5'-UMP + H2O
-
Rattus norvegicus p-nitrophenol + isopropyl-5'-UMP
-
?
polymer synthesized from NAD+ + H2O chain length 27-30 Rattus norvegicus ?
-
?
RNA + H2O hydrolyzed very slowly Rattus norvegicus nucleoside 5'-phosphates
-
?

Temperature Stability [°C]

Temperature Stability Minimum [°C] Temperature Stability Maximum [°C] Comment Organism
70
-
pH 7.3, 5 min, complete loss of activity Rattus norvegicus

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
10.1
-
nitrophenyl uridine 5'-monophosphate Rattus norvegicus
10.5
-
NAD Rattus norvegicus

pH Range

pH Minimum pH Maximum Comment Organism
8 10 nitrophenyl uridine 5'-monphosphate, pH 8: about 15% of maximum activity, pH 10: about 10% of maximum activity Rattus norvegicus