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Literature summary for 3.1.13.2 extracted from

  • Ko, C.; Shin, Y.C.; Park, W.J.; Kim, S.; Kim, J.; Ryu, W.S.
    Residues Arg703, Asp777, and Arg781 of the RNase H domain of hepatitis B virus polymerase are critical for viral DNA synthesis (2014), J. Virol., 88, 154-163.
    View publication on PubMedView publication on EuropePMC
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Protein Variants

Protein Variants Comment Organism
D777A the mutant shows loss of catalytic activity Hepatitis B virus
D778A the mutant shows a defect in enzyme activity Hepatitis B virus
K745A the mutant shows a defect in enzyme activity Hepatitis B virus
R703A the mutant shows loss of catalytic activity Hepatitis B virus
R781A the mutant shows a defect in enzyme activity Hepatitis B virus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
DNA-RNA hybrid + H2O Hepatitis B virus
-
 ?
-
 ?

Organism

Organism UniProt Comment Textmining
Hepatitis B virus
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
DNA-RNA hybrid + H2O
-
 Hepatitis B virus ?
-
 ?

Synonyms

Synonyms Comment Organism
RNase H
-
 Hepatitis B virus