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Literature summary for 3.1.13.2 extracted from

  • Roquebert, B.; Marcelin, A.G.
    The involvement of HIV-1 RNAse H in resistance to nucleoside analogues (2008), J. Antimicrob. Chemother., 61, 973-975.
    View publication on PubMed
Search for more literature for 3.1.13.2

Protein Variants

Protein Variants Comment Organism
D549N have remarkable effects on viral replication by reducing the level of RNAse H activity Human immunodeficiency virus 1
D549N site-directed mutagenesis, leads to a slowing down in the degradation of the RNA strand, decreases the frequency of reverse transcriptase template-switching by 2fold Human immunodeficiency virus 1
E478Q have remarkable effects on viral replication by reducing the level of RNAse H activity Human immunodeficiency virus 1
H539N site-directed mutagenesis, leads to a slowing down in the degradation of the RNA strand, decreases the frequency of reverse transcriptase template-switching by 2fold Human immunodeficiency virus 1
K476A reduces the virus titre Human immunodeficiency virus 1
K65R nucleoside reverse transcriptase inhibitor resistance mutation Human immunodeficiency virus 1
L74V nucleoside reverse transcriptase inhibitor resistance mutation Human immunodeficiency virus 1
M184I nucleoside reverse transcriptase inhibitor resistance mutation Human immunodeficiency virus 1
additional information site-directed mutagenesis can affect the binding enzyme/substrate, resulting in a decrease in the RNAse H activity. Mutations in positions 448 and 505 have no effect on virus titre Human immunodeficiency virus 1
N474A reduces the virus titre Human immunodeficiency virus 1
Q151N nucleoside reverse transcriptase inhibitor resistance mutation Human immunodeficiency virus 1
Q500A reduces the virus titre Human immunodeficiency virus 1
T473A abolishes HIV-1 replication Human immunodeficiency virus 1

Inhibitors

Inhibitors Comment Organism Structure
additional information resistance to nucleoside reverse transcriptase inhibitors Human immunodeficiency virus 1

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Human immunodeficiency virus 1 RNAse H is implicated in catalysing the degradation of the RNA strand during conversion of the viral genome into double-stranded DNA ?
-
 ?

Organism

Organism UniProt Comment Textmining
Human immunodeficiency virus 1
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information RNAse H is implicated in catalysing the degradation of the RNA strand during conversion of the viral genome into double-stranded DNA Human immunodeficiency virus 1 ?
-
 ?

Synonyms

Synonyms Comment Organism
ribonuclease H carboxy-terminal domain of reverse transcriptase from amino acid 427 to amino acid 560 Human immunodeficiency virus 1
RNase H
-
 Human immunodeficiency virus 1