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Literature summary for 3.1.13.2 extracted from

  • Kleinicke, C.; Fischer, H.; Flugel.R.M.
    Ribonuclease H activities associated with Herpes simplex virus (1974), Biochem. Biophys. Res. Commun., 60, 1491-1498.
    View publication on PubMed
Search for more literature for 3.1.13.2

Cloned(Commentary)

Cloned (Comment) Organism
-
 Herpes simplex virus

Inhibitors

Inhibitors Comment Organism Structure
p-hydroxymercuribenzoate 5 mM lead to 90% inhibition Herpes simplex virus

Metals/Ions

Metals/Ions Comment Organism Structure
Mg2+ substitutes for Mg2+ in presence of EDTA Herpes simplex virus
Mn2+
-
 Herpes simplex virus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
DNA-RNA hybrid duplex + H2O Herpes simplex virus
-
 oligonucleotides terminated with 5'-phosphate and 3'-hydroxyl moiety
-
 ?
DNA-RNA hybrid duplex + H2O Herpes simplex virus HSV
-
 oligonucleotides terminated with 5'-phosphate and 3'-hydroxyl moiety
-
 ?

Organism

Organism UniProt Comment Textmining
Herpes simplex virus
-
 HSV
-
Herpes simplex virus HSV
-
 HSV
-

Storage Stability

Storage Stability Organism
activity is repidly lost upon repeated thawing Herpes simplex virus

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
DNA-RNA hybrid duplex + H2O
-
 Herpes simplex virus oligonucleotides terminated with 5'-phosphate and 3'-hydroxyl moiety
-
 ?
DNA-RNA hybrid duplex + H2O
-
 Herpes simplex virus HSV oligonucleotides terminated with 5'-phosphate and 3'-hydroxyl moiety
-
 ?
additional information not: ss DNA Herpes simplex virus ?
-
 ?
additional information not: ss RNA Herpes simplex virus ?
-
 ?
additional information not: ds RNA Herpes simplex virus ?
-
 ?
additional information not: ds DNA Herpes simplex virus ?
-
 ?
additional information not: ss DNA Herpes simplex virus HSV ?
-
 ?
additional information not: ss RNA Herpes simplex virus HSV ?
-
 ?
additional information not: ds RNA Herpes simplex virus HSV ?
-
 ?
additional information not: ds DNA Herpes simplex virus HSV ?
-
 ?