Literature summary for 3.1.13.1 extracted from

Rother, S.; Bartels, M.; Schweda, A.T.; Resch, K.; Pallua, N.; Nourbakhsh, M.
NF-kappaB-repressing factor phosphorylation regulates transcription elongation via its interactions with 5'->3' exoribonuclease 2 and negative elongation factor (2016), FASEB J., 30, 174-185 .

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Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
additional information	Homo sapiens	interactions between NKRF, 5'->3' exoribonuclease 2 (XRN2) and the negative elongation factor (NELF)-E in HeLa cells	?	-	?

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	Q9H0D6	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
HeLa cell	strong interaction between NKRF-TAP and endogenous XRN2 in HeLa cells	Homo sapiens	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
additional information	interactions between NKRF, 5'->3' exoribonuclease 2 (XRN2) and the negative elongation factor (NELF)-E in HeLa cells	Homo sapiens	?	-	?

Synonyms

Synonyms	Comment	Organism
5'->3' exoribonuclease 2	-	Homo sapiens
XRN2	-	Homo sapiens

General Information

General Information	Comment	Organism
metabolism	NF-kappaB-repressing factor phosphorylation regulates transcription elongation via its interactions with 5'->3' exoribonuclease 2 and negative elongation factor. Interleukin-1 has a more drastic effect on NELF-E or XRN2 binding to NKRF than the M1 mutation	Homo sapiens
physiological function	interactions between NKRF, 5'->3' exoribonuclease 2 (XRN2) and the negative elongation factor (NELF)-E in HeLa cells. Interleukin IL-1 stimulation leads to decrease in NKRF amino acids 421-429 phosphorylation and dissociation of NELF-E and XRN2 by concomitant resumption of transcription elongation of a synthetic reporter or the endogenous NKRF target gene, interleukin IL-8. 5'->3' exoribonuclease 2 (XRN2) is implicated in inhibition of transcription elongation via the termination of initiated transcripts in many RNA Pol II-dependent promoters	Homo sapiens

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Release 2023.1 (January 2023)