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Literature summary for 3.1.12.1 extracted from

  • Krupovic, M.; Cvirkaite-Krupovic, V.; Prangishvili, D.; Koonin, E.
    Evolution of an archaeal virus nucleocapsid protein from the CRISPR-associated Cas4 nuclease (2015), Biol. Direct, 10, 65-70 .
No PubMed abstract available
Search for more literature for 3.1.12.1

Cloned(Commentary)

Cloned (Comment) Organism
in TTV1, the Cas4 gene has been split into two, with the N-terminal portion becoming TP1, and lost some of the catalytic amino acid residues, apparently resulting in the inactivation of the nuclease, sequence analysis and comparison of TTV1 nucleocapsid protein TP1 Thermoproteus tenax virus 1

Organism

Organism UniProt Comment Textmining
Thermoproteus tenax virus 1 P19270 TTV1
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Synonyms

Synonyms Comment Organism
CRISPR-associated Cas4 nuclease
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 Thermoproteus tenax virus 1
TTV1 nucleocapsid protein TP1
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 Thermoproteus tenax virus 1

General Information

General Information Comment Organism
evolution a capsid protein, TTV1 nucleocapsid protein TP1, of a filamentous archaeal virus, Thermoproteus tenax virus 1 (TTV1), evolved relatively recently through exaptation from a CRISPR-associated Cas4 nuclease. The corresponding surface in Cas4 is shielded by the C-terminal domain, suggesting that removal of this domain is a prerequisite for the transformation of the ancestral TTV1 Cas4 into a nucleocapsid protein Thermoproteus tenax virus 1
malfunction in TTV1, the Cas4 gene has been split into two, with the N-terminal portion becoming TP1, and lost some of the catalytic amino acid residues, apparently resulting in the inactivation of the nuclease Thermoproteus tenax virus 1
additional information three-dimensional structure modelling Thermoproteus tenax virus 1
physiological function the nucleocapsid protein (TP1) of Thermoproteus tenax virus 1 (TTV1) is a derivative of the Cas4 nuclease, a component of the CRISPR-Cas adaptive immunity system Thermoproteus tenax virus 1