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Literature summary for 3.1.11.2 extracted from
- Characterization of Caenorhabditis elegans exonuclease-3 and evidence that a Mg2+-dependent variant exhibits a distinct mode of action on damaged DNA (2005), Biochemistry, 44, 12835-12848.
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
| expression as a GST-fusion protein in Saccharomyces cerevisiae | Caenorhabditis elegans |
Protein Variants
| Protein Variants | Comment | Organism |
|---|---|---|
| E58A | altered Mg2+-binding properties, 3'-diesterase activity is reduced when compared to the native enzyme | Caenorhabditis elegans |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Caenorhabditis elegans | - |
- |
- |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
| recombinant fusion protein | Caenorhabditis elegans |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| double-stranded DNA + H2O | - |
Caenorhabditis elegans | ? | - |
? |  |
| additional information | the enzyme possesses strong apurinic/apyrimidinic endonuclease and 3'-diesterase activity, no significant level of 3'-5' exonuclease activity following incision at apurinic/apyrimidinic site | Caenorhabditis elegans | ? | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| EXO-3 | - |
Caenorhabditis elegans |
| exonuclease-3 | - |
Caenorhabditis elegans |
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