Protein Variants | Comment | Organism |
---|---|---|
A153V | the mutation is associated with colorectal cancer and cancer of the small intestine | Homo sapiens |
E109K | the mutation is associated with colorectal cancer | Homo sapiens |
E589K | the mutation is associated with gastric cancer, lung cancer, hepatocellular carcinoma, melanoma, and glioblastoma | Homo sapiens |
E670G | the mutation is associated with gastric cancer, breast cancer, oral cancer, lung cancer, melanoma, and glioblastoma | Homo sapiens |
N279S | the mutation is associated with breast cancer and pancreatic cancer | Homo sapiens |
P757L | the mutation is associated with colorectal cancer, pancreatic cancer, gastric cancer, breast cancer, oral cancer, lung cancer, and melanoma | Homo sapiens |
R723G/R723S | the mutation is associated with gastric cancer, breast cancer, oral cancer, and lung cancer | Homo sapiens |
T439M | the mutation is associated with colorectal cancer | Homo sapiens |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
DNA containing double Holliday junctions + H2O | Homo sapiens | - |
? | - |
? | |
double stranded DNA containing mismatches + H2O | Homo sapiens | - |
? | - |
? | |
gapped DNA containing mismatches + H2O | Homo sapiens | - |
? | - |
? | |
additional information | Homo sapiens | the enzyme has 5'->3' exonuclease activity, as well as 5' structure specific DNA endonuclease activity and 5'->3' RNase H activity | ? | - |
? | |
nicked DNA containing mismatches + H2O | Homo sapiens | - |
? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | Q9UQ84 | - |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
DNA containing double Holliday junctions + H2O | - |
Homo sapiens | ? | - |
? | |
double stranded DNA containing mismatches + H2O | - |
Homo sapiens | ? | - |
? | |
gapped DNA containing mismatches + H2O | - |
Homo sapiens | ? | - |
? | |
additional information | the enzyme has 5'->3' exonuclease activity, as well as 5' structure specific DNA endonuclease activity and 5'->3' RNase H activity | Homo sapiens | ? | - |
? | |
nicked DNA containing mismatches + H2O | - |
Homo sapiens | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
Exo1 | - |
Homo sapiens |
exonuclease 1 | - |
Homo sapiens |
General Information | Comment | Organism |
---|---|---|
malfunction | a defect of the enzyme is associated with different types of cancers, including Lynch Syndrome, breast, ovarian, lung, pancreatic, and gastric tract cancer | Homo sapiens |
physiological function | the enzyme contributes to checkpoint progression and to several DNA repair pathways involved in reducing DNA replication stress, for example, in mismatch repair, translesion DNA synthesis, nucleotide excision repair, double-strand break repair, and checkpoint activation to restart stalled DNA forks | Homo sapiens |