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Literature summary for 3.1.11.1 extracted from

  • Nakai, W.; Westmoreland, J.; Yeh, E.; Bloom, K.; Resnick, M.A.
    Chromosome integrity at a double-strand break requires exonuclease 1 and MRX (2011), DNA Repair, 10, 102-110.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.1.11.1

Protein Variants

Protein Variants Comment Organism
additional information when the exo1DELTA or the exo1-D173A nuclease mutations are combined with a rad50DELTA mutation, the frequency of large budded cells with a CRB following I-SceI induction increases to 80% or 65% with HO, induction of CRBs by HO-endonuclease is also increased in an exo1DELTA mutant Saccharomyces cerevisiae

Organism

Organism UniProt Comment Textmining
Saccharomyces cerevisiae
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-
-

Synonyms

Synonyms Comment Organism
Exo1
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 Saccharomyces cerevisiae
exonuclease 1
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 Saccharomyces cerevisiae

General Information

General Information Comment Organism
malfunction nearly all double-strand breaks are converted to chromosome breaks in cells lacking both exonuclease 1 activity and RAD50/MRE11/XRS2, MRX, complex Saccharomyces cerevisiae
physiological function DNA processing or resection carried out in the presence of Exo1 is efficient at preventing the double-strand break to chromosome break transition and that the exonuclease activity associated with exonuclease 1 plays a major role. Some feature of exonuclease processing or resection at a double-strand break is critical for maintaining broken chromosome ends in close proximity, additional role for Exo1 of maintaining chromosome continuity upon introduction of a double-strand break Saccharomyces cerevisiae