Application | Comment | Organism |
---|---|---|
molecular biology | Exo1 plays an important role in the induction of apoptosis by unrepaired O6-methylguanines | Mus musculus |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | Mus musculus | Exo1-null mutant, is impaired in the excision step of mismatch repair. Absence of Exo1 activity diminishes/completely eliminates O6-methylguanines-induced apoptosis. Ablation of Exo1 function renders Mgmt-null cells just as resistant to alkylation-induced cytotoxicity as wild-type cells. Exo1 defect leads to a variable tissue-specific alkylation resistance phenotype. Mgmt-/- Exo1-/- mice show decreased alkylation-induced splenic atrophy, decreased alkylation-induced apoptosis in thymus and spleen tissues and decreased alkylation-induced bone marrow ablation compared with that in Mgmt-/- animals | ? | - |
? | |
additional information | Mus musculus C57/BL6J | Exo1-null mutant, is impaired in the excision step of mismatch repair. Absence of Exo1 activity diminishes/completely eliminates O6-methylguanines-induced apoptosis. Ablation of Exo1 function renders Mgmt-null cells just as resistant to alkylation-induced cytotoxicity as wild-type cells. Exo1 defect leads to a variable tissue-specific alkylation resistance phenotype. Mgmt-/- Exo1-/- mice show decreased alkylation-induced splenic atrophy, decreased alkylation-induced apoptosis in thymus and spleen tissues and decreased alkylation-induced bone marrow ablation compared with that in Mgmt-/- animals | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mus musculus | - |
C57BL/6J mice | - |
Mus musculus C57/BL6J | - |
C57BL/6J mice | - |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
bone marrow | - |
Mus musculus | - |
MEF cell | - |
Mus musculus | - |
spleen | - |
Mus musculus | - |
thymus | - |
Mus musculus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | Exo1-null mutant, is impaired in the excision step of mismatch repair. Absence of Exo1 activity diminishes/completely eliminates O6-methylguanines-induced apoptosis. Ablation of Exo1 function renders Mgmt-null cells just as resistant to alkylation-induced cytotoxicity as wild-type cells. Exo1 defect leads to a variable tissue-specific alkylation resistance phenotype. Mgmt-/- Exo1-/- mice show decreased alkylation-induced splenic atrophy, decreased alkylation-induced apoptosis in thymus and spleen tissues and decreased alkylation-induced bone marrow ablation compared with that in Mgmt-/- animals | Mus musculus | ? | - |
? | |
additional information | Exo1-null mutant, is impaired in the excision step of mismatch repair. Absence of Exo1 activity diminishes/completely eliminates O6-methylguanines-induced apoptosis. Ablation of Exo1 function renders Mgmt-null cells just as resistant to alkylation-induced cytotoxicity as wild-type cells. Exo1 defect leads to a variable tissue-specific alkylation resistance phenotype. Mgmt-/- Exo1-/- mice show decreased alkylation-induced splenic atrophy, decreased alkylation-induced apoptosis in thymus and spleen tissues and decreased alkylation-induced bone marrow ablation compared with that in Mgmt-/- animals | Mus musculus C57/BL6J | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
Exo1 | - |
Mus musculus |
exonuclease 1 | - |
Mus musculus |