Inhibitors | Comment | Organism | Structure |
---|---|---|---|
additional information | hydroxyurea induces degradation of Exo1b via polyubiquitinylation | Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | Homo sapiens | the enzyme is involved in repair of DNA which is damaged by UV radiation, the constitutive enzyme is phosphorylated and rapidly degraded upon arrest of DNA replication in S phase via the ubiquitin-proteasome pathway, regulation, overview | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Posttranslational Modification | Comment | Organism |
---|---|---|
phosphoprotein | Exo1b is phosphorylated in response to inhibition of DNA synthesis signaling for the rapid degradation of the enzyme via the ubiquitin-proteasome pathway | Homo sapiens |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
HEK-293T cell | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | the enzyme is involved in repair of DNA which is damaged by UV radiation, the constitutive enzyme is phosphorylated and rapidly degraded upon arrest of DNA replication in S phase via the ubiquitin-proteasome pathway, regulation, overview | Homo sapiens | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
EXO1b | - |
Homo sapiens |
exonuclease 1b | - |
Homo sapiens |