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Literature summary for 3.1.1.98 extracted from
- Wnt/Notum spatial feedback inhibition controls neoblast differentiation to regulate reversible growth of the planarian brain (2015), Development, 142, 4217-4229 .
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Schmidtea mediterranea | F8U830 | - |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| brain | - |
Schmidtea mediterranea | - |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| Notum | - |
Schmidtea mediterranea |
General Information
| General Information | Comment | Organism |
|---|---|---|
| physiological function | notum has a role in promoting brain cell numbers during conditions of brain cell loss through tissue remodeling. Notum inhibits wnt11-6 to control brain size in regenerative degrowth and growth. Notum and wnt11-6 antagonism acts in an essentially constitutive process to control brain cell number, potentially through the determination and maintenance of a size set-point for the planarian brain. Notum and wnt11-6 regulate neoblast differentiation to influence brain size. Inhibition of notum does not significantly alter the density of neurons within the brain or average neuronal cell size, indicating that notum is likely to regulate brain:body proportion principally through the regulation of brain cell number | Schmidtea mediterranea |
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Release 2023.1 (January 2023)
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