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Literature summary for 3.1.1.96 extracted from
- Role of D-aminoacyl-tRNA deacylase beyond chiral proofreading as a cellular defense against glycine mischarging by AlaRS (2017), eLife, 6, e24001 .
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| Gly-tRNAAla + H2O | Escherichia coli | the enzyme has a crucial role in preventing the accumulation of mischarged Gly-tRNAAla species. The enzyme effectively decouples glycine mischarged on tRNAAla, key cellular role as a glycine deacylator | Gly + tRNAAla | - |
? |  |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Escherichia coli | - |
- |
- |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| Gly-tRNAAla + H2O | - |
Escherichia coli | Gly + tRNAAla | - |
? | |
| Gly-tRNAAla + H2O | the enzyme has a crucial role in preventing the accumulation of mischarged Gly-tRNAAla species. The enzyme effectively decouples glycine mischarged on tRNAAla, key cellular role as a glycine deacylator | Escherichia coli | Gly + tRNAAla | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| DTD | - |
Escherichia coli |
General Information
| General Information | Comment | Organism |
|---|---|---|
| malfunction | DTD knockout in AlaRS editing-defective background causes pronounced toxicity in Escherichia coli even at low-glycine levels which is alleviated by alanine supplementation | Escherichia coli |
| metabolism | the enzym effectively decouples glycine mischarged on tRNAAla, key cellular role as a glycine deacylator | Escherichia coli |
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