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Literature summary for 3.1.1.90 extracted from

  • Chander, P.; Gentleman, S.; Poliakov, E.; Redmond, T.
    Aromatic residues in the substrate cleft of RPE65 protein govern retinol isomerization and modulate its progression (2012), J. Biol. Chem., 287, 30552-30559.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.1.1.90

Protein Variants

Protein Variants Comment Organism
F103I mutant produces reduced amounts of 13-cis-retinol and reduced production of 11-cis-retinol compared to wild-type Mus musculus
F103L mutant produces increased amounts of 13-cis-retinol but reduced production of 11-cis-retinol compared to wild-type Mus musculus
F103W mutant produces reduced amounts of 13-cis-retinol and reduced production of 11-cis-retinol compared to wild-type Mus musculus
F103Y mutant produces reduced amounts of 13-cis-retinol and reduced production of 11-cis-retinol compared to wild-type Mus musculus
F312L mutant shows severly impaired enzymatic activity Mus musculus
F312W mutant shows severly impaired enzymatic activity Mus musculus
F312Y mutant shows severly impaired enzymatic activity Mus musculus
F418A mutant shows severly impaired enzymatic activity Mus musculus
F418L mutant shows severly impaired enzymatic activity Mus musculus
F418W mutant shows severly impaired enzymatic activity Mus musculus
F418Y mutant shows severly impaired enzymatic activity Mus musculus
F526A mutant shows a increased production level of 13-cis-retinol compared to wild-type Mus musculus
F526L mutant shows a decreased production level of 11-cis-retinol compared to wild-type Mus musculus
F526W mutant shows a decreased production level of 11-cis-retinol compared to wild-type Mus musculus
F526Y mutant shows a decreased production level of 11-cis-retinol compared to wild-type Mus musculus
F61A mutant shows severly impaired enzymatic activity Mus musculus
F61L mutant shows severly impaired enzymatic activity Mus musculus
F61W mutant shows severly impaired enzymatic activity Mus musculus
F61Y mutant shows severly impaired enzymatic activity Mus musculus
Y338A mutant produces increased amounts of 13-cis-retinol but reduced production of 11-cis-retinol compared to wild-type Mus musculus
Y338F mutant produces similar amounts of 13-cis-retinol but reduced production of 11-cis-retinol compared to wild-type Mus musculus
Y338L mutant produces similar amounts of 13-cis-retinol but reduced production of 11-cis-retinol compared to wild-type Mus musculus
Y338W mutant produces similar amounts of 13-cis-retinol but reduced production of 11-cis-retinol compared to wild-type Mus musculus

Organism

Organism UniProt Comment Textmining
Mus musculus
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
all-trans retinyl ester + H2O
-
 Mus musculus 13-cis retinol + ?
-
 ?
all-trans retinyl ester + H2O
-
 Mus musculus 11-cis retinol + ?
-
 ?

Synonyms

Synonyms Comment Organism
Rpe65
-
 Mus musculus